Literature DB >> 6290280

Iron-dependent free radical damage to DNA and deoxyribose. Separation of TBA-reactive intermediates.

J M Gutteridge, D Toeg.   

Abstract

1. Iron-dependent free radical damage to DNA and deoxyribose results in the formation of thiobarbituric acid (TBA) reactive intermediates. 2. These intermediates have been compared chromatographically and spectrophotometrically after incubation with the enzymes xanthine oxidase and peroxidase. 3. Loss of TBA-reactivity occurred in the bleomycin-iron(II) derived products incubated with xanthine oxidase and in a standard solution of sodium malondialdehyde incubated with peroxidase.

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Year:  1982        PMID: 6290280     DOI: 10.1016/0020-711x(82)90071-4

Source DB:  PubMed          Journal:  Int J Biochem        ISSN: 0020-711X


  9 in total

1.  Ferrous-salt-promoted damage to deoxyribose and benzoate. The increased effectiveness of hydroxyl-radical scavengers in the presence of EDTA.

Authors:  J M Gutteridge
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

2.  Methylene blue plus light mediates 8-hydroxy 2'-deoxyguanosine formation in DNA preferentially over strand breakage.

Authors:  J E Schneider; S Price; L Maidt; J M Gutteridge; R A Floyd
Journal:  Nucleic Acids Res       Date:  1990-02-11       Impact factor: 16.971

3.  Thiobarbituric acid-reactive malondialdehyde formation during superoxide-dependent, iron-catalyzed lipid peroxidation: influence of peroxidation conditions.

Authors:  D R Janero; B Burghardt
Journal:  Lipids       Date:  1989-02       Impact factor: 1.880

4.  Potentiation by sulfide of hydrogen peroxide-induced killing of Escherichia coli.

Authors:  E H Berglin; J Carlsson
Journal:  Infect Immun       Date:  1985-09       Impact factor: 3.441

5.  Fluorescent histochemical localization of lipid peroxidation during brain reperfusion following cardiac arrest.

Authors:  B C White; A Daya; D J DeGracia; B J O'Neil; J M Skjaerlund; S Trumble; G S Krause; J A Rafols
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

6.  Reactivity of hydroxyl and hydroxyl-like radicals discriminated by release of thiobarbituric acid-reactive material from deoxy sugars, nucleosides and benzoate.

Authors:  J M Gutteridge
Journal:  Biochem J       Date:  1984-12-15       Impact factor: 3.857

7.  DNA strand breaks in mammalian tissues induced by methylarsenics.

Authors:  K Yamanaka; A Hasegawa; R Sawamura; S Okada
Journal:  Biol Trace Elem Res       Date:  1989 Jul-Sep       Impact factor: 3.738

8.  Changes in dry state hemoglobin over time do not increase the potential for oxidative DNA damage in dried blood.

Authors:  April Marrone; Jack Ballantyne
Journal:  PLoS One       Date:  2009-04-08       Impact factor: 3.240

9.  Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders.

Authors:  Maryam Khoubnasabjafari; Khalil Ansarin; Abolghasem Jouyban
Journal:  Bioimpacts       Date:  2015-07-26
  9 in total

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