Literature DB >> 6290115

Effects of muramyl dipeptide on superoxide anion release and on anti-microbial activity of human macrophages.

C B Wilson, J Bohnsack, W M Weaver.   

Abstract

Exposure of human monocyte derived macrophages to muramyl dipeptide in vitro increased phorbol myristate acetate-stimulated O2- release by these cells; the activity of such macrophages against Toxoplasma gondii or against Staphylococcus aureus was not increased. The failure of muramyl dipeptide to enhance human macrophage anti-microbial activity correlated with the failure of muramyl dipeptide to enhance O2- release in response to phagocytic stimuli. These results and those previously published by others indicate that muramyl dipeptide may enhance release of certain inflammatory mediators (O2- and endogenous pyrogen) without enhancing the anti-microbial activity of human macrophages.

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Year:  1982        PMID： 6290115      PMCID： PMC1536489     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  15 in total

1.  A simple technique for eliminating interference by detergents in the Lowry method of protein determination.

Authors:  J R Dulley; P A Grieve
Journal:  Anal Biochem       Date:  1975-03       Impact factor: 3.365

2.  Increased superoxide anion production by immunologically activated and chemically elicited macrophages.

Authors:  R B Johnston; C A Godzik; Z A Cohn
Journal:  J Exp Med       Date:  1978-07-01       Impact factor: 14.307

Review 3.  Biological activities of muramyl dipeptide, a synthetic glycopeptide analogous to bacterial immunoregulating agents.

Authors:  L Chedid; F Audibert; A G Johnson
Journal:  Prog Allergy       Date:  1978

4.  Superoxide dismutases in polymorphonuclear leukocytes.

Authors:  M L Salin; J M McCord
Journal:  J Clin Invest       Date:  1974-10       Impact factor: 14.808

5.  Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing.

Authors:  B W Catlin
Journal:  J Infect Dis       Date:  1973-08       Impact factor: 5.226

6.  The pyrogenicity of the synthetic adjuvant muramyl dipeptide and two structural analogues.

Authors:  C A Dinarello; R J Elin; L Chedid; S M Wolff
Journal:  J Infect Dis       Date:  1978-12       Impact factor: 5.226

7.  Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs.

Authors:  M A Parant; F M Audibert; L A Chedid; M R Level; P L Lefrancier; J P Choay; E Lederer
Journal:  Infect Immun       Date:  1980-03       Impact factor: 3.441

8.  Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.

Authors:  M J Pabst; R B Johnston
Journal:  J Exp Med       Date:  1980-01-01       Impact factor: 14.307

9.  Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates.

Authors:  H W Murray; C W Juangbhanich; C F Nathan; Z A Cohn
Journal:  J Exp Med       Date:  1979-10-01       Impact factor: 14.307

10.  Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens.

Authors:  C B Wilson; V Tsai; J S Remington
Journal:  J Exp Med       Date:  1980-02-01       Impact factor: 14.307
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  1 in total

1.  Cellular defenses against Toxoplasma gondii in newborns.

Authors:  C B Wilson; J E Haas
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808
  1 in total

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