Literature DB >> 6290032

Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721.

F Valeriote, S Tolen.   

Abstract

The radioprotective agent WR-2721 was examined for its effects on modifying the cytotoxicity of HN2 against normal and tumor cells in the AKR mouse. Quantitation was carried out by the spleen colony assay for both normal hematopoietic stem cells and AKR leukemia cells. Protection from drug toxicity and normal cell cytotoxicity was noted. Potentiation of cytotoxicity to AKR leukemia was found.

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Year:  1982        PMID： 6290032

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  9 in total

Review 1.  Clinical and preclinical modulation of chemotherapy-induced toxicity in patients with cancer.

Authors:  K Hoekman; W J van der Vijgh; J B Vermorken
Journal:  Drugs       Date:  1999-02       Impact factor: 9.546

Review 2.  A risk-benefit assessment of amifostine in cytoprotection.

Authors:  M Mabro; S Faivre; E Raymond
Journal:  Drug Saf       Date:  1999-11       Impact factor: 5.606

Review 3.  Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome.

Authors:  C R Culy; C M Spencer
Journal:  Drugs       Date:  2001       Impact factor: 9.546

4.  Zebrafish as a model system to screen radiation modifiers.

Authors:  Misun Hwang; Cha Yong; Luigi Moretti; Bo Lu
Journal:  Curr Genomics       Date:  2007-09       Impact factor: 2.236

Review 5.  Amifostine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as a radioprotector and cytotoxic chemoprotector.

Authors:  C M Spencer; K L Goa
Journal:  Drugs       Date:  1995-12       Impact factor: 9.546

6.  Influence of single and multiple doses of amifostine on the efficacy and the pharmacokinetics of carboplatin in mice.

Authors:  A E Korst; E Boven; M L van der Sterre; A M Fichtinger-Schepman; W J van der Vijgh
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

Review 7.  The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects.

Authors:  G A Hospers; E A Eisenhauer; E G de Vries
Journal:  Br J Cancer       Date:  1999-05       Impact factor: 7.640

8.  Amifostine protection against mitomycin-induced chromosomal breakage in fanconi anaemia lymphocytes.

Authors:  Ricardo M Camelo; Fernanda S G Kehdy; Carlos E Salas; Miriam T P Lopes
Journal:  Molecules       Date:  2008-08-21       Impact factor: 4.411

9.  The effect of amifostine on differentiation of the human megakaryoblastic Dami cell line.

Authors:  Hai-Tao Wang; Bo Yang; Bo Hu; Xiao-Hua Chi; Long-Long Luo; Hong-Qi Yang; Xiao-Ling Lang; Jing Geng; Chun-Xia Qiao; Yan Li; Xiao-Xiong Wu; Hong-Li Zhu; Ming Lv; Xue-Chun Lu
Journal:  Cancer Med       Date:  2016-05-26       Impact factor: 4.452
  9 in total

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