Literature DB >> 6289968

Capsaicin blocks one class of K+ channels in the frog node of Ranvier.

J M Dubois.   

Abstract

Capsaicin (10-20 microM) blocks reversibly one component of the K+ current (IKf2) in frog node of Ranvier. The block is enhanced with depolarization but it is not voltage-dependent indicating that the affinity of receptor sites for capsaicin is larger with the channels in the open configuration. The results provide pharmacological evidence of the existence within the nodal membrane of two classes of fast K+ channels, in addition to the slow K+ channels.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6289968     DOI： 10.1016/0006-8993(82)90820-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  15 in total

1.  Heterogeneous distribution of fast and slow potassium channels in myelinated rat nerve fibres.

Authors:  J Röper; J R Schwarz
Journal:  J Physiol       Date:  1989-09       Impact factor: 5.182

Review 2.  Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.

Authors:  Dirk Bucher; Jean-Marc Goaillard
Journal:  Prog Neurobiol       Date:  2011-06-17       Impact factor: 11.685

3.  Characteristics of type I and type II K+ channels in rabbit cultured Schwann cells.

Authors:  M D Baker; J M Ritchie
Journal:  J Physiol       Date:  1996-01-01       Impact factor: 5.182

4.  The influence of capsaicin on membrane currents in dorsal root ganglion neurones of guinea-pig and chicken.

Authors:  M Petersen; F K Pierau; M Weyrich
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657

Review 5.  An emerging pharmacology of peptide toxins targeted against potassium channels.

Authors:  E Moczydlowski; K Lucchesi; A Ravindran
Journal:  J Membr Biol       Date:  1988-10       Impact factor: 1.843

Review 6.  Potassium channel blockers and neuronal function.

Authors:  A L Harvey; E G Rowan; A J Anderson
Journal:  Pflugers Arch       Date:  1989       Impact factor: 3.657

7.  Effect of capsaicin and analogues on potassium and calcium currents and vanilloid receptors in Xenopus embryo spinal neurones.

Authors:  F M Kuenzi; N Dale
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

8.  Interactions between molecules of a steroid anaesthetic (alphaxalone) and ionic channels of nodal membrane in voltage-clamped myelinated nerve fibre.

Authors:  E Benoit; M R Carratù; D Mitolo-Chieppa
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

9.  Non-stationary fluctuations of the potassium conductance at the node of ranvier of the frog.

Authors:  F Conti; B Hille; W Nonner
Journal:  J Physiol       Date:  1984-08       Impact factor: 5.182

10.  Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin.

Authors:  S Bevan; S Hothi; G Hughes; I F James; H P Rang; K Shah; C S Walpole; J C Yeats
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.