Literature DB >> 6289733

Effect of ribavirin on Rous sarcoma virus transformation.

F J Jenkins, Y C Chen.   

Abstract

Ribavirin inhibited the expression of cellular transformation in normal rat kidney cells transformed by a temperature-sensitive mutant of rous sarcoma virus and chicken embryo fibroblasts infected with either a temperature-sensitive mutant or wild-type Rous sarcoma virus. Ribavirin also inhibited replication of the Rous sarcoma viruses in chicken embryo fibroblasts. The effect of ribavirin on cellular transformation was not permanent, as removal of the drug resulted in reversion to the transformed phenotype. The concentration of ribavirin necessary to inhibit the expression of cellular transformation was cytostatic for the cell lines used in this study.

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Year:  1981        PMID： 6289733      PMCID： PMC181433          DOI： 10.1128/AAC.19.2.364

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Reversion from transformed to normal phenotype by inhibition of protein synthesis in rat kidney cells infected with a temperature-sensitive mutant of Rous sarcoma virus.

Authors:  J F Ash; P K Vogt; S J Singer
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

Review 2.  Ribavirin: an antiviral agent.

Authors:  R W Sidwell; R K Robins; I W Hillyard
Journal:  Pharmacol Ther       Date:  1979       Impact factor: 12.310

3.  The selective isolation of temperature-sensitive mutants of Rous sarcoma virus.

Authors:  J A Wyke
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

4.  Characteristics of two new avian tumor virus subgroups.

Authors:  R G Duff; P K Vogt
Journal:  Virology       Date:  1969-09       Impact factor: 3.616

5.  Effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) on Friend leukemia virus infections in mice.

Authors:  R W Sidwell; L B Allen; J H Huffman; J T Witkowski; L N Sinon
Journal:  Proc Soc Exp Biol Med       Date:  1975-03

6.  Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.

Authors:  D G Streeter; J T Witkowski; G P Khare; R W Sidwell; R J Bauer; R K Robins; L N Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1973-04       Impact factor: 11.205

7.  Properties of mammalian cells transformed by temperature-sensitive mutants of avian sarcoma virus.

Authors:  Y C Chen; M J Hayman; P K Vogt
Journal:  Cell       Date:  1977-07       Impact factor: 41.582

8.  Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole.

Authors:  J K Lowe; L Brox; J F Henderson
Journal:  Cancer Res       Date:  1977-03       Impact factor: 12.701

9.  In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.

Authors:  J H Huffman; R W Sidwell; G P Khare; J T Witkowski; L B Allen; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1973-02       Impact factor: 5.191

10.  Mechanism and specificity of action of ribavirin.

Authors:  M J Browne
Journal:  Antimicrob Agents Chemother       Date:  1979-06       Impact factor: 5.191
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  3 in total

1.  Visna virus as an in vitro model for human immunodeficiency virus and inhibition by ribavirin, phosphonoformate, and 2',3'-dideoxynucleosides.

Authors:  K B Frank; P A McKernan; R A Smith; D F Smee
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

2.  Broad-spectrum synergistic antiviral activity of selenazofurin and ribavirin.

Authors:  J J Kirsi; P A McKernan; N J Burns; J A North; B K Murray; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1984-10       Impact factor: 5.191

3.  The potential of nucleotide analogs as inhibitors of retroviruses and tumors.

Authors:  R K Robins
Journal:  Pharm Res       Date:  1984-01       Impact factor: 4.200
  3 in total

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