Literature DB >> 628844

Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture.

T Papayannopoulou, B Nakamoto, J Buckley, S Kurachi, P E Nute, G Stamatoyannopoulos.   

Abstract

Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.

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Year:  1978        PMID： 628844     DOI： 10.1126/science.628844

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

Review 1.  Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.

Authors:  Andrew Wilber; Arthur W Nienhuis; Derek A Persons
Journal:  Blood       Date:  2011-02-14       Impact factor: 22.113

2.  Regulation of fetal hemoglobin synthesis in sickle cell anemia.

Authors:  D G Nathan
Journal:  Trans Am Clin Climatol Assoc       Date:  1987

3.  Cellular regulation of hemoglobin switching: evidence for inverse relationship between fetal hemoglobin synthesis and degree of maturity of human erythroid cells.

Authors:  T Papayannopoulou; T Kalmantis; G Stamatoyannopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

4.  Cellular mechanisms for increased fetal hemoglobin production in culture. Evidence for continuous commitment to fetal hemoglobin production during burst formation.

Authors:  G J Dover; M Ogawa
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

5.  Proportion of fetal hemoglobin synthesis decreases during erythroid cell maturation.

Authors:  D H Chui; S C Wong; M W Enkin; M Patterson; R A Ives
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

6.  Sickle beta 0 thalassemia in Eastern Saudi Arabia.

Authors:  M E Pembrey; R P Perrine; W G Wood; D J Weatherall
Journal:  Am J Hum Genet       Date:  1980-01       Impact factor: 11.025

Review 7.  Concise Review: Advanced Cell Culture Models for Diamond Blackfan Anemia and Other Erythroid Disorders.

Authors:  Anna Rita Migliaccio; Lilian Varricchio
Journal:  Stem Cells       Date:  2017-12-05       Impact factor: 6.277

8.  Serum factors can modulate the developmental clock of gamma- to beta-globin gene switching in somatic cell hybrids.

Authors:  G Zitnik; Q Li; G Stamatoyannopoulos; T Papayannopoulou
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

9.  Fetal haemoglobin, sickling, and thalassaemia: a therapeutic lead?

Authors: 
Journal:  Br Med J       Date:  1978-07-01

10.  Control of the simian fetal hemoglobin switch at the progenitor cell level.

Authors:  B P Alter; B T Jackson; J M Lipton; G J Piasecki; P L Jackson; M Kudisch; D G Nathan
Journal:  J Clin Invest       Date:  1981-02       Impact factor: 14.808
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