Literature DB >> 6288016

Human gamma-melanotropin precursor potentiates corticotropin-induced adrenal steroidogenesis by stimulating mRNA synthesis.

E A Al-Dujaili, B C Williams, C R Edwards, P Salacinski, P J Lowry.   

Abstract

Circulating human gamma-melanotropin precursor (76 amino acids) [N-POC(1-76) enhances the corticosterone and aldosterone response to corticotropin by isolated perfused rat adrenal cells [Al-Dujaili, Hope, Estivariz, Lowry & Edwards (1981) Nature (London) 291, 156-159]. Actinomycin D (4 x 10(-6) mol/litre) did not significantly affect corticotropin-induced corticosterone or aldosterone outputs, but completely inhibited the potentiating action of gamma-melanotropin precursor on rat adrenal cells. This suggests that the precursor enhances corticotropin-induced steroidogenesis via an increase in available mRNA produced from DNA transcription.

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Year:  1982        PMID： 6288016      PMCID： PMC1158345          DOI： 10.1042/bj2040301

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Effect of cordycepin on CRF stimulation and steroid inhibition of ACTH secretion by rat pituitary cells.

Authors:  W J Brattin; R Portanova
Journal:  Mol Cell Endocrinol       Date:  1978-01       Impact factor: 4.102

2.  Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450.

Authors:  E R Simpson; J L McCarthy; J A Peterson
Journal:  J Biol Chem       Date:  1978-05-10       Impact factor: 5.157

Review 3.  On the mechanism of action of ACTH.

Authors:  L D Garren; G N Gill; H Masui; G M Walton
Journal:  Recent Prog Horm Res       Date:  1971

4.  Purification and characterization of a gamma-melanotropin precursor from frozen human pituitary glands.

Authors:  F E Estivariz; J Hope; C McLean; P J Lowry
Journal:  Biochem J       Date:  1980-10-01       Impact factor: 3.857

5.  Most of the coding region of rat ACTH beta--LPH precursor gene lacks intervening sequences.

Authors:  J Drouin; H M Goodman
Journal:  Nature       Date:  1980-12-11       Impact factor: 49.962

6.  Measurement of the dynamics of stimulation and inhibition of steroidogenesis in isolated rat adrenal cells by using column perfusion.

Authors:  P J Lowry; C McMartin
Journal:  Biochem J       Date:  1974-08       Impact factor: 3.857

7.  Adrenocortical response to corticotropin is potentiated by part of the amino-terminal region of pro-corticotropin/endorphin.

Authors:  R C Pedersen; A C Brownie
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

8.  Development of a radioimmunoassay for an amino-terminal peptide of pro-opiocortin containing the gamma-MSH region: measurement and characterization in human plasma.

Authors:  J Hope; S J Ratter; F E Estivariz; L McLoughlin; P J Lowry
Journal:  Clin Endocrinol (Oxf)       Date:  1981-09       Impact factor: 3.478

9.  Circulating human pituitary pro-gamma-melanotropin enhances the adrenal response to ACTH.

Authors:  E A Al-Dujaili; J Hope; F E Estivariz; P J Lowry; C R Edwards
Journal:  Nature       Date:  1981-05-14       Impact factor: 49.962

Review 10.  ACTH stimulation on cholesterol side chain cleavage activity of adrenocortical mitochondria. Transfer of the stimulus from plasma membrane to mitochondria.

Authors:  T Kimura
Journal:  Mol Cell Biochem       Date:  1981-04-27       Impact factor: 3.396
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  1 in total

1.  A radioimmunoassay for N-terminal peptide of chum salmon proopiocortin.

Authors:  A Takahashi; H Kawauchi; T Hirano
Journal:  Fish Physiol Biochem       Date:  1987-03       Impact factor: 2.794
  1 in total

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