Literature DB >> 6288010

Forskolin as an activator of cyclic AMP accumulation and secretion in blowfly salivary glands.

I Litosch, Y Saito, J N Fain.   

Abstract

Forskolin is a diterpene that activates adenylate cyclase in a variety of mammalian cells. In addition of forskolin to blowfly salivary glands increased cyclic AMP accumulation and salivary secretion. There was a small increase in transepithelial movement of labelled Ca2+. Forskolin did not induce breakdown of labelled phosphatidylinositol or inhibit the stimulation of phosphatidylinositol breakdown caused by 5-hydroxytryptamine. These data indicate that forskolin can mimic all the effects of 5-hydroxytryptamine on salivary-gland secretion that have been attributed to cyclic AMP.

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Year:  1982        PMID： 6288010      PMCID： PMC1158326          DOI： 10.1042/bj2040147

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  The interaction of cyclic nucleotides and calcium in the control of cellular activity.

Authors:  M J Berridge
Journal:  Adv Cyclic Nucleotide Res       Date:  1975

2.  Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland.

Authors:  J N Fain; M J Berridge
Journal:  Biochem J       Date:  1979-01-15       Impact factor: 3.857

3.  Changes in cyclic AMP and cyclic GMP concentrations during the action of 5-hydroxytryptamine on an insect salivary gland.

Authors:  J P Heslop; M J Berridge
Journal:  Biochem J       Date:  1980-10-15       Impact factor: 3.857

4.  Regulation of adenylate cyclase and cyclic AMP phosphodiesterase by 5-hydroxytryptamine and calcium ions in blowfly salivary-gland homogenates.

Authors:  I Litosch; M Fradin; M Kasaian; H S Lee; J N Fain
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

5.  Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion.

Authors:  W T Prince; M J Berridge; H Rasmussen
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

6.  Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

Authors:  K B Seamon; W Padgett; J W Daly
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

7.  The role of 5-hydroxytryptamine and cyclic AMP in the control of fluid secretion by isolated salivary glands.

Authors:  M J Berridge
Journal:  J Exp Biol       Date:  1970-08       Impact factor: 3.312

8.  Studies on the mechanism of fluid secretion by isolated salivary glands of Calliphora.

Authors:  M J Berridge; B D Lindley; W T Prince
Journal:  J Exp Biol       Date:  1976-04       Impact factor: 3.312

9.  Stimulus-secretion coupling in an insect salivary gland: cell activation by elevated potassium concentrations.

Authors:  M J Berridge; B D Lindley; W T Prince
Journal:  J Exp Biol       Date:  1975-06       Impact factor: 3.312
  9 in total
  3 in total

1.  Regulation of adenylate cyclase and cyclic AMP phosphodiesterase by 5-hydroxytryptamine and calcium ions in blowfly salivary-gland homogenates.

Authors:  I Litosch; M Fradin; M Kasaian; H S Lee; J N Fain
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

2.  Forskolin increases osmotic water permeability of rabbit cortical collecting tubule.

Authors:  M A Dillingham; J K Kim; M F Horster; R J Anderson
Journal:  J Membr Biol       Date:  1984       Impact factor: 1.843

3.  3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.

Authors:  J E Brown; U B Kaupp; C C Malbon
Journal:  J Physiol       Date:  1984-08       Impact factor: 5.182
  3 in total

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