Literature DB >> 6288004

The inhibitory effect of Zn2+ on poly(ADP-ribose) polymerase activity and its reversal.

A G Larsen, A C Ostvold, J Holtlund, T Kristensen, S G Laland.   

Abstract

Zn2+ inhibits purified poly(ADP-ribose) polymerase (50% inhibition at 10 microM). Furthermore poly (ADP-ribose) polymerase present in nuclei and metaphase chromosome clusters is also inhibited by Zn2+. The inactivated enzyme could be re-activated by dithiothreitol. The concentration of Zn2+ needed to affect the enzyme activity in the organelles is sufficiently low for it to have a possible role in controlling the activity of this chromatin-bound enzyme.

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Year:  1982        PMID： 6288004      PMCID： PMC1158257          DOI： 10.1042/bj2030511

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Poly(ADP-ribose) polymerase from Ehrlich ascites-tumour cells. Amino acid composition, N-terminal analysis and chemical cleavage of the purified protein.

Authors:  J Holtlund; T Kristensen; K Sletten
Journal:  Biochem J       Date:  1980-03-01       Impact factor: 3.857

2.  Preparation and physical characterization of a homogeneous population of monomeric nucleosomes from HeLa cells.

Authors:  J P Whitlock; R T Simpson
Journal:  Nucleic Acids Res       Date:  1976-09       Impact factor: 16.971

Review 3.  Clinical, biochemical, and pharmacological role of zinc.

Authors:  A S Prasad
Journal:  Annu Rev Pharmacol Toxicol       Date:  1979       Impact factor: 13.820

4.  Studies on phosphomannose isomerase. II. Characterization as a zinc metalloenzyme.

Authors:  R W Gracy; E A Noltmann
Journal:  J Biol Chem       Date:  1968-08-10       Impact factor: 5.157

5.  Interactions of metal ions with polynucleotides and related compounds. XI. The reversible unwinding and rewinding of deoxyribonucleic acid by zinc (II) Ions through temperature manipulation.

Authors:  Y A Shin; G L Eichhorn
Journal:  Biochemistry       Date:  1968-03       Impact factor: 3.162

6.  Incorporation of 65Zn in rat liver nuclei.

Authors:  U Weser; E Bischoff
Journal:  Eur J Biochem       Date:  1970-02

7.  On the presence of poly(ADP-ribose) polymerase activity in metaphase chromosomes from HeLa S3 cells.

Authors:  J Holtlund; T Kristensen; A C Ostvold; S G Laland
Journal:  FEBS Lett       Date:  1980-07-11       Impact factor: 4.124

8.  Sulfhydryl reagents prevent dephosphorylation and proteolysis of histones in isolated HeLa metaphase chromosomes.

Authors:  J R Paulson
Journal:  Eur J Biochem       Date:  1980-10

9.  Concentration of 17 elements in subcellular fractions of beef heart tissue determined by neutron activation analysis.

Authors:  P O Wester
Journal:  Biochim Biophys Acta       Date:  1965-09-27

10.  Binding of inhibitory metals to yeast enolase.

Authors:  J I Elliott; J M Brewer
Journal:  J Inorg Biochem       Date:  1980-07       Impact factor: 4.155
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  4 in total

Review 1.  Natural inhibitors of poly(ADP-ribose) polymerase-1.

Authors:  Marek Banasik; Todd Stedeford; Robert P Strosznajder
Journal:  Mol Neurobiol       Date:  2012-04-04       Impact factor: 5.590

2.  Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis.

Authors:  C T Sheline; M M Behrens; D W Choi
Journal:  J Neurosci       Date:  2000-05-01       Impact factor: 6.167

Review 3.  Inhibitors and activators of ADP-ribosylation reactions.

Authors:  M Banasik; K Ueda
Journal:  Mol Cell Biochem       Date:  1994-09       Impact factor: 3.396

4.  The role of zinc in 5',5'-diadenosine tetraphosphate production by aminoacyl-transfer RNA synthetases.

Authors:  S Blanquet; P Plateau; A Brevet
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396
  4 in total

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