Literature DB >> 6287580

Numbers of receptor sites from Scatchard graphs: facts and fantasies.

I M Klotz.   

Abstract

Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.

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Year:  1982        PMID： 6287580     DOI： 10.1126/science.6287580

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  98 in total

1.  The result of equilibrium-constant calculations strongly depends on the evaluation method used and on the type of experimental errors.

Authors:  H Fuchs; R Gessner
Journal:  Biochem J       Date:  2001-10-15       Impact factor: 3.857

2.  Consequences of a subtle sialic acid modification on the murine polyomavirus receptor.

Authors:  M Herrmann; C W von der Lieth; P Stehling; W Reutter; M Pawlita
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

3.  Probing tRNA interaction with biogenic polyamines.

Authors:  Amin Ahmed Ouameur; Philippe Bourassa; Heidar-Ali Tajmir-Riahi
Journal:  RNA       Date:  2010-08-20       Impact factor: 4.942

4.  Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

Authors:  J B Konopka; S M Margarit; P Dube
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

5.  Induction of the high-affinity nerve growth factor receptor on embryonic chicken sensory nerve cells by elevated potassium.

Authors:  D J Ennulat; R W Stach
Journal:  Neurochem Res       Date:  1987-10       Impact factor: 3.996

6.  Rapid and Reversible High-Affinity Binding of the Dinitroaniline Herbicide Oryzalin to Tubulin from Zea mays L.

Authors:  J. D. Hugdahl; L. C. Morejohn
Journal:  Plant Physiol       Date:  1993-07       Impact factor: 8.340

7.  Competitive Inhibition of High-Affinity Oryzalin Binding to Plant Tubulin by the Phosphoric Amide Herbicide Amiprophos-Methyl.

Authors:  J. V. Murthy; H. H. Kim; V. R. Hanesworth; J. D. Hugdahl; L. C. Morejohn
Journal:  Plant Physiol       Date:  1994-05       Impact factor: 8.340

Review 8.  Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status.

Authors:  M B Davidson
Journal:  West J Med       Date:  1985-02

9.  Fast and high-affinity binding of B-lymphotropic papovavirus to human B-lymphoma cell lines.

Authors:  M Herrmann; M Oppenländer; M Pawlita
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: a possible explanation of antibody-induced insulin resistance.

Authors:  C Grunfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205
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