Literature DB >> 6287287

A transforming gene present in human sarcoma cell lines.

C J Marshall, A Hall, R A Weiss.   

Abstract

Morphological transformation of NIH/3T3 cells by transfection with DNA has been used to identify transforming sequences in human tumours. Transforming activity has been reported for DNAs isolated from bladder, mammary, colon and lung carcinomas, neuroblastoma, lymphoid and myeloid tumours. Each of these tissues seems to contain different transforming sequences except for the colon and lung tumours where the same sequence seems to be involved. We now report that in two different human sarcoma cell lines, a fibrosarcoma and an embryonal rhabdomyosarcoma, the DNAs have transforming activity. The transforming gene is the same in both sarcomas but differs from the activated sequences detected in other tumours. We have also found that the transforming gene has no detectable homology to eight retrovirus oncogenes tested.

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Year:  1982        PMID： 6287287     DOI： 10.1038/299171a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  44 in total

1.  Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway.

Authors:  S Gupta; R Plattner; C J Der; E J Stanbridge
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

2.  Ras history: The saga continues.

Authors:  Adrienne D Cox; Channing J Der
Journal:  Small GTPases       Date:  2010-07

3.  Proteomic analysis of peritrophic membrane (PM) from the midgut of fifth-instar larvae, Bombyx mori.

Authors:  Xiaolong Hu; Lin Chen; Xingwei Xiang; Rui Yang; Shaofang Yu; Xiaofeng Wu
Journal:  Mol Biol Rep       Date:  2011-07-02       Impact factor: 2.316

4.  NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.

Authors:  Ann-Kathrin Eisfeld; Sebastian Schwind; Kevin W Hoag; Christopher J Walker; Sandya Liyanarachchi; Ravi Patel; Xiaomeng Huang; Joseph Markowitz; Wenrui Duan; Gregory A Otterson; William E Carson; Guido Marcucci; Clara D Bloomfield; Albert de la Chapelle
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-28       Impact factor: 11.205

Review 5.  Human cancer and cellular oncogenes.

Authors:  S Nishimura; T Sekiya
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

Review 6.  Role of inositol trisphosphate as a second messenger in signal transduction processes: an essay.

Authors:  N N Osborne; A B Tobin; H Ghazi
Journal:  Neurochem Res       Date:  1988-03       Impact factor: 3.996

7.  Transforming mutations of RAC guanosine triphosphatases in human cancers.

Authors:  Masahito Kawazu; Toshihide Ueno; Kenji Kontani; Yoshitaka Ogita; Mizuo Ando; Kazutaka Fukumura; Azusa Yamato; Manabu Soda; Kengo Takeuchi; Yoshio Miki; Hiroyuki Yamaguchi; Takahiko Yasuda; Tomoki Naoe; Yoshihiro Yamashita; Toshiaki Katada; Young Lim Choi; Hiroyuki Mano
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205

8.  A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

Authors:  M H Kraus; Y Yuasa; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

9.  Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications.

Authors:  Athanassios Kyrgidis; Thrasivoulos-George Tzellos; Stefanos Triaridis
Journal:  J Carcinog       Date:  2010-04-01

10.  Identification and expression analysis of ras gene in silkworm, Bombyx mori.

Authors:  Takehiko Ogura; Anjiang Tan; Takuya Tsubota; Takayo Nakakura; Takahiro Shiotsuki
Journal:  PLoS One       Date:  2009-11-25       Impact factor: 3.240
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