| Literature DB >> 6287135 |
J E Morley, A S Levine, J Kneip, M Grace.
Abstract
As abdominal vagotomy blocks the satiety effect of cholecystokinin-octapeptide, we felt it would be worthwhile to examine whether the satiety effect of any of the other putative satiety neuropeptides was mediated through the vagus. We confirmed that the satiety effect of peripherally administered cholecystokinin (10 micrograms/kg) was mediated through the vagus. In addition, the satiety effect of peripherally administered TRH (8 mg/kg) also was not present in vagotomized animals. Vagotomy had no effect on the satiety effects of peripherally administered bombesin, calcitonin and naloxone. Nor did vagotomy alter the satiety effect produced by central administration of bombesin, TRH, calcitonin nor naloxone.Entities:
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Year: 1982 PMID： 6287135 DOI： 10.1016/0024-3205(82)90476-3
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037