Literature DB >> 6286749

Graves' IgG stimulation of continuously cultured rat thyroid cells: a sensitive and potentially useful clinical assay.

P Vitti, W A Valente, F S Ambesi-Impiombato, G F Fenzi, A Pinchera, L D Kohn.   

Abstract

A continuously cultured line of normal rat thyroid (FRTL) cells can be stimulated by immunoglobulin preparations from patients with Graves' disease as measured by increases in intracellular cAMP levels. Responsiveness is concentration-dependent but is delayed in time relative to thyrotropin. Additionally, the cells respond to Graves' immunoglobulins which have no long-acting thyroid stimulator (LATS) activity and are negative when adenylate cyclase stimulation in human thyroid membrane preparations is assayed. No correlation exists between the stimulation activity and the ability of a Graves' immunoglobulin preparation to inhibit thyrotropin binding; cells are responsive even in the presence of such inhibitor activity.

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Year:  1982        PMID： 6286749     DOI： 10.1007/BF03349476

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  7 in total

1.  Thyrotropin receptors in thyroid plasma membranes. Characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion.

Authors:  R L Tate; H I Schwartz; J M Holmes; L D Kohn
Journal:  J Biol Chem       Date:  1975-08-25       Impact factor: 5.157

2.  Humoral immunity in Graves' disease.

Authors:  J M McKenzie; M Zakarija; A Sato
Journal:  Clin Endocrinol Metab       Date:  1978-03

3.  Culture of hormone-dependent functional epithelial cells from rat thyroids.

Authors:  F S Ambesi-Impiombato; L A Parks; H G Coon
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

4.  Thyroid membrane ADP ribosyltransferase activity. Stimulation by thyrotropin and activity in functioning and nonfunctioning rat thyroid cells in culture.

Authors:  M J De Wolf; P Vitti; F S Ambesi-Impiombato; L D Kohn
Journal:  J Biol Chem       Date:  1981-12-10       Impact factor: 5.157

5.  Comparison between thyroid stimulating and tsh-binding inhibiting immunoglobulins of Graves' disease.

Authors:  E Macchia; G F Fenzi; F Monzani; F Lippi; P Vitti; L Grasso; L Bartalena; L Baschieri; A Pinchera
Journal:  Clin Endocrinol (Oxf)       Date:  1981-08       Impact factor: 3.478

6.  Thyroid-stimulating immunoglobulin bioassay using cultured human thyroid cells.

Authors:  W E Hinds; N Takai; B Rapoport; S Filetti; O H Clark
Journal:  J Clin Endocrinol Metab       Date:  1981-06       Impact factor: 5.958

7.  Thyroid-stimulating antibody (TSab) detected in sera of Graves' patients using human thyroid cell cultures.

Authors:  R S Toccafondi; S Aterini; M A Medici; C M Rotella; A Tanini; R Zonefrati
Journal:  Clin Exp Immunol       Date:  1980-06       Impact factor: 4.330
  7 in total
  21 in total

1.  Detection and characterization of autoantibodies blocking the TSH-dependent cAMP production using FRTL-5 cells.

Authors:  L Chiovato; P Vitti; A Lombardi; G Lopez; F Santini; E Macchia; G F Fenzi; C Mammoli; S Battiato; A Pinchera
Journal:  J Endocrinol Invest       Date:  1987-08       Impact factor: 4.256

2.  Measurement of TSAb directly in serum using FRTL-5 cells.

Authors:  P Vitti; L Chiovato; G Lopez; A Lombardi; F Santini; C Mammoli; P Bassi; M Gryczynska; E Schipani; M Tosti-Balducci
Journal:  J Endocrinol Invest       Date:  1988-04       Impact factor: 4.256

Review 3.  The thyrotropin receptor and its role in Graves' disease.

Authors:  B Rees Smith; C R Rickards; E Davies Jones; Y Kajita; P R Buckland; F M Creagh; R D Howells; F Hashim; A B Parkes; V B Petersen
Journal:  J Endocrinol Invest       Date:  1985-04       Impact factor: 4.256

4.  Clinical applications of assays for thyrotropin-receptor antibodies in Graves' disease.

Authors:  J Ginsberg; C von Westarp
Journal:  CMAJ       Date:  1986-05-15       Impact factor: 8.262

5.  Kappa/lambda immunoglobulin distribution in Graves' thyroid-stimulating antibodies. Simultaneous analysis of C lambda gene polymorphisms.

Authors:  R C Williams; N J Marshall; K Kilpatrick; J Montano; P M Brickell; M Goodall; P A Ealey; B Shine; A P Weetman; R K Craig
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

Review 6.  Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa.

Authors:  Sandra M McLachlan; Basil Rapoport
Journal:  Thyroid       Date:  2013-01       Impact factor: 6.568

7.  The expression of the microsomal/peroxidase autoantigen in human thyroid cells is thyrotrophin-dependent.

Authors:  L Chiovato; P Vitti; P Cucchi; C Mammoli; P Carajon; A Pinchera
Journal:  Clin Exp Immunol       Date:  1989-04       Impact factor: 4.330

8.  Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease.

Authors:  W A Valente; P Vitti; Z Yavin; E Yavin; C M Rotella; E F Grollman; R S Toccafondi; L D Kohn
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

9.  Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin.

Authors:  L Persani; M Tonacchera; P Beck-Peccoz; P Vitti; C Mammoli; L Chiovato; R Elisei; G Faglia; M Ludgate; G Vassart
Journal:  J Endocrinol Invest       Date:  1993 Jul-Aug       Impact factor: 4.256

10.  Detection of thyroid-stimulating antibodies in thyroid diseases, employing rat thyroid fragment perifusion.

Authors:  J R Attali; P Valensi; D Darnis; C Weisselberg; J Sebaoun
Journal:  J Endocrinol Invest       Date:  1987-04       Impact factor: 4.256
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