Literature DB >> 6286327

Caerulein and cholecystokinin suppress beta-endorphin-induced analgesia in the rat.

S Itoh, G Katsuura, Y Maeda.   

Abstract

The analgesic action of beta-endorphin, as observed in the hot plate test with rats, was effectively suppressed by intracerebroventricular (i.c.v.) injection of caerulein and cholecystokinin octapeptide (CCK-8). The effect of caerulein was particularly striking; this peptide in doses of more than 0.09 nM lessened or abolished the analgesic effect of beta-endorphin in a dose of 0.7 nM. On the other hand, non sulfated CCK-8 had no significant effect on beta-endorphin-induced analgesia.

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Year:  1982        PMID： 6286327     DOI： 10.1016/0014-2999(82)90089-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.

Authors:  Yeon Sun Lee; Richard S Agnes; Hamid Badghisi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Journal:  J Med Chem       Date:  2006-03-09       Impact factor: 7.446

2.  Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.

Authors:  Yeon Sun Lee; Richard S Agnes; Peg Davis; Shou-wu Ma; Hamid Badghisi; Josephine Lai; Frank Porreca; Victor J Hruby
Journal:  J Med Chem       Date:  2007-01-11       Impact factor: 7.446

Review 3.  Spinal opioid systems in inflammation.

Authors:  L Stanfa; A Dickenson
Journal:  Inflamm Res       Date:  1995-06       Impact factor: 4.575

4.  Opposite role of CCKA and CCKB receptors in the modulation of endogenous enkephalin antidepressant-like effects.

Authors:  C Smadja; R Maldonado; S Turcaud; M C Fournie-Zaluski; B P Roques
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

5.  Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole.

Authors:  M Derrien; C Durieux; B P Roques
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

6.  PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.

Authors:  Z Wiesenfeld-Hallin; X J Xu; J Hughes; D C Horwell; T Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

7.  CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat.

Authors:  X J Xu; Z Wiesenfeld-Hallin; J Hughes; D C Horwell; T Hökfelt
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

8.  Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.

Authors:  F Noble; M Derrien; B P Roques
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

9.  Dexamethasone-induced selective inhibition of the central mu opioid receptor: functional in vivo and in vitro evidence in rodents.

Authors:  S Pieretti; A Di Giannuario; M R Domenici; S Sagratella; A Capasso; L Sorrentino; A Loizzo
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

Review 10.  Cholecystokinin and pain: a review.

Authors:  J W McRoberts
Journal:  Anesth Prog       Date:  1986 Mar-Apr
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