Literature DB >> 6286126

Ionic mechanism of a voltage-dependent current elicited by cyclic AMP.

T C Pellmar.   

Abstract

Intracellular pressure injection of cyclic AMP induces a slow voltage-dependent inward current in some neurons of Aplysia californica. The time course, voltage dependence, and ionic sensitivities of this response are nearly identical to those of the voltage-dependent calcium current induced by serotonin in the same preparation. The response to cyclic AMP is unaffected by changes in the extracellular concentration of chloride or potassium. The current is slowly but minimally reduced by a sodium-free solution. The calcium channel blocker, cadmium, blocks the current elicited by injection of cyclic AMP. The data presented here suggest that cyclic AMP can induce a voltage-dependent calcium current.

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Year:  1981        PMID： 6286126     DOI： 10.1007/bf00736041

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  34 in total

Review 1.  Cyclic nucleotides and nervous system function.

Authors:  J A Nathanson
Journal:  Physiol Rev       Date:  1977-04       Impact factor: 37.312

Review 2.  Relationships between calcium and cyclic nucleotides in cell activation.

Authors:  H Rasmussen; D B Goodman
Journal:  Physiol Rev       Date:  1977-07       Impact factor: 37.312

3.  Cyclic AMP induced by serotonin modulates the activity of an identified synapse in Aplysia by facilitating the active permeability to calcium.

Authors:  T Shimahara; L Tauc
Journal:  Brain Res       Date:  1977-05-20       Impact factor: 3.252

4.  The ins and outs of calcium transport in squid axons: internal and external ion activation of calcium efflux.

Authors:  M P Blaustein
Journal:  Fed Proc       Date:  1976-12

Review 5.  Ca spike.

Authors:  S Hagiwara
Journal:  Adv Biophys       Date:  1973

6.  Intracellular calcium injection causes increased potassium conductance in Aplysia nerve cells.

Authors:  R W Meech
Journal:  Comp Biochem Physiol A Comp Physiol       Date:  1972-06-01

7.  A pressure system for intracellular and extracellular ejections of picoliter volumes.

Authors:  R E McCaman; D G McKenna; J K Ono
Journal:  Brain Res       Date:  1977-11-04       Impact factor: 3.252

8.  Chloride distribution in Aplysia neurones.

Authors:  P Ascher; D Kunze; T O Neild
Journal:  J Physiol       Date:  1976-04       Impact factor: 5.182

Review 9.  Calmodulin plays a pivotal role in cellular regulation.

Authors:  W Y Cheung
Journal:  Science       Date:  1980-01-04       Impact factor: 47.728

10.  Three pharmacologically distinct potassium channels in molluscan neurones.

Authors:  S H Thompson
Journal:  J Physiol       Date:  1977-02       Impact factor: 5.182
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  11 in total

1.  Free calcium transients and oscillations in nerve cells.

Authors:  P G Kostyuk; P V Belan; A V Tepikin
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

2.  Phosphorylation of ion channels.

Authors:  I B Levitan
Journal:  J Membr Biol       Date:  1985       Impact factor: 1.843

3.  Intracellular injection of protein kinase inhibitor blocks the serotonin-induced increase in K+ conductance in Aplysia neuron R15.

Authors:  W B Adams; I B Levitan
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

4.  Compartmentalization of cyclic AMP elevation in neurons of Aplysia californica.

Authors:  P Hockberger; T Yamane
Journal:  Cell Mol Neurobiol       Date:  1987-03       Impact factor: 5.046

5.  Synaptic stimulation alters protein phosphorylation in vivo in a single Aplysia neuron.

Authors:  J R Lemos; I Novak-Hofer; I B Levitan
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

6.  Alteration of calcium conductances and outward current by cyclic adenosine monophosphate (cAMP) in neurons of Limax maximus.

Authors:  P Hockberger; J A Connor
Journal:  Cell Mol Neurobiol       Date:  1984-12       Impact factor: 5.046

7.  Does cyclic 3' ,5'-adenosine monophosphate act as second messenger in a voltage-dependent response to 5-hydroxytryptamine in Aplysia?

Authors:  T C Pellmar
Journal:  Br J Pharmacol       Date:  1981-12       Impact factor: 8.739

8.  Aminergic and peptidergic amplification of intracellular cyclic AMP levels in a molluscan neural network.

Authors:  T Yamane; A Gelperin
Journal:  Cell Mol Neurobiol       Date:  1987-09       Impact factor: 5.046

9.  The regulation of phosphorylation of a specific protein in synaptosomal fractions from Drosophila heads: the effects of light and two visual mutants.

Authors:  L E Kelly
Journal:  Cell Mol Neurobiol       Date:  1983-06       Impact factor: 5.046

10.  A novel membrane sodium current induced by injection of cyclic nucleotides into gastropod neurones.

Authors:  J A Connor; P Hockberger
Journal:  J Physiol       Date:  1984-09       Impact factor: 5.182
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