Literature DB >> 6285735

Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus-infected cells.

P V McGuirt, P A Furman.   

Abstract

The effect of acyclovir on DNA synthesized in HSV-1-infected cells was examined. Viral DNA synthesis was significantly reduced in the presence of 10 microM acyclovir monitored by cRNA-DNA hybridization and isopycnic centrifugation in cesium chloride. DNA synthesized in infected cells in the presence of acyclovir appeared to be chain-terminated when evaluated by rate zonal centrifugation in alkaline sucrose. Cellular DNA synthesis in actively replicating uninfected cells in the presence of acyclovir was evaluated by isopycnic centrifugation. Cellular DNA synthesis appeared unaffected at concentrations of acyclovir up to 100 microM.

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Year:  1982        PMID： 6285735     DOI： 10.1016/0002-9343(82)90066-3

Source DB:  PubMed          Journal:  Am J Med        ISSN： 0002-9343            Impact factor:   4.965


  13 in total

1.  Inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replication.

Authors:  John E Tavis; Hong Wang; Ann E Tollefson; Baoling Ying; Maria Korom; Xiaohong Cheng; Feng Cao; Katie L Davis; William S M Wold; Lynda A Morrison
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

2.  Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.

Authors:  C L Talarico; T C Burnette; W H Miller; S L Smith; M G Davis; S C Stanat; T I Ng; Z He; D M Coen; B Roizman; K K Biron
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

3.  Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses.

Authors:  Peter J Ireland; John E Tavis; Michael P D'Erasmo; Danielle R Hirsch; Ryan P Murelli; Mark M Cadiz; Bindi S Patel; Ankit K Gupta; Tiffany C Edwards; Maria Korom; Eileen A Moran; Lynda A Morrison
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

4.  Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir.

Authors:  J S Cannon; F Hamzeh; S Moore; J Nicholas; R F Ambinder
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

5.  Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates.

Authors:  J L Martin; M N Ellis; P M Keller; K K Biron; S N Lehrman; D W Barry; P A Furman
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191

6.  Prolonged herpes simplex virus latency in vitro after treatment of infected cells with acyclovir and human leukocyte interferon.

Authors:  A C Scheck; B Wigdahl; E De Clercq; F Rapp
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

Review 7.  Antiviral therapy of acute herpes zoster in older patients.

Authors:  K Herne; R Cirelli; P Lee; S K Tyring
Journal:  Drugs Aging       Date:  1996-02       Impact factor: 3.923

8.  Inhibition of glycosylation of bovine herpesvirus 1 glycoproteins by the thymidine analog (E)-5-(2 Bromovinyl)-2'-deoxyuridine.

Authors:  V Misra; R C Nelson; L A Babiuk
Journal:  Antimicrob Agents Chemother       Date:  1983-06       Impact factor: 5.191

Review 9.  Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.

Authors:  D M Richards; A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1983-11       Impact factor: 9.546

10.  Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.

Authors:  Ashwani Kumar Vashishtha; Robert D Kuchta
Journal:  Biochemistry       Date:  2016-02-11       Impact factor: 3.162
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