| Literature DB >> 6285109 |
I Kojima, S Yoshihara, E Ogata.
Abstract
In an attempt to evaluate the role of endogenous digitalis-like substance in the genesis of deoxycorticosterone (DOCA) -salt hypertension, the effects of intravenous anti-digoxin antibody on the blood pressure response were observed in male Wistar rats that underwent heminephrectomy followed by treatment with DOCA and saline. Administration of anti-digoxin antibody caused a marked decrease in the blood pressure which continued for about an hour. Such a change in the blood pressure was not observed in pertinent control animals. Thus, it seems that endogenous digitalis-like substance plays an important role in the genesis of DOCA-salt hypertension.Entities:
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Year: 1982 PMID： 6285109 DOI： 10.1016/0024-3205(82)90313-7
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037