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Literature DB >> 6284133

Evidence that poly(ADP-ribose) polymerase is involved in the loss of NAD from cultured rat liver cells.

A J Paine, C M Allen, B W Durkacz, S Shall.

Abstract

Rat hepatocytes cultured from 24h lose 60% of their NAD content. By using the differential response to inhibitors of the two major enzymes that catabolize NAD in mammalian cells, it is shown that poly(ADP-ribose) polymerase is responsible for the loss of NAD. The relevance of this observation to the use of cultured hepatocytes for the study of DNA repair induced by carcinogens is discussed.

Entities: Chemical Gene Species

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Year: 1982 PMID： 6284133 PMCID： PMC1158142 DOI： 10.1042/bj2020551

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

11 in total

1. The involvement of poly(ADP-ribose) polymerase in the degradation of NAD caused by gamma-radiation and N-methyl-N-nitrosourea.

Authors: C J Skidmore; M I Davies; P M Goodwin; H Halldorsson; P J Lewis; S Shall; A A Zia'ee
Journal: Eur J Biochem Date: 1979-11-01

2. Poly (ADP-ribose) polymerase activity in nucleotide permeable cells.

Authors: H Halldorsson; D A Gray; S Shall
Journal: FEBS Lett Date: 1978-01-15 Impact factor: 4.124

3. Nicotinamide adenine dinucleotide (NAD) stimulation of DNA synthesis by human bone marrow cells.

Authors: L P Schacter; P J Burke
Journal: Biochem Biophys Res Commun Date: 1978-02-14 Impact factor: 3.575

4. Studies on the biosynthesis of NAD from nicotinamide and on the intracellular pyridine nucleotide cycle in isolated perfused rat liver.

Authors: J Keller; M Liersch; H Grunicke
Journal: Eur J Biochem Date: 1971-09-24

5. Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5'-methyl nicotinamide.

Authors: J B Clark; G M Ferris; S Pinder
Journal: Biochim Biophys Acta Date: 1971-04-29

6. Studies on the biosynthesis of nicotinamide adenine dinucleotide. 3. Comparative in vivo studies on nicotinic acid, nicotinamide, and quinolinic acid as precursors of nicotinamide adenine dinucleotide.

Authors: H Ijichi; A Ichiyama; O Hayaishi
Journal: J Biol Chem Date: 1966-08-25 Impact factor: 5.157

10. Relationship between the ability of nicotinamide to maintain nicotinamide-adenine dinucleotide in rat liver cell culture and its effect on cytochrome P-450.

Authors: A J Paine; L J Hockin; R F Legg
Journal: Biochem J Date: 1979-11-15 Impact factor: 3.857

3 in total

1. The role of 5-aminolaevulinate synthase, haem oxygenase and ligand formation in the mechanism of maintenance of cytochrome P-450 concentration in hepatocyte culture.

Authors: L J Hockin; A J Paine
Journal: Biochem J Date: 1983-03-15 Impact factor: 3.857

2. Immunochemical quantification of cytochrome P450IA and IIB subfamilies in the livers of metyrapone-treated rats. Relevance to the ability of metyrapone to prevent the loss of cytochrome P-450 in rat hepatocyte culture.

Authors: K Shean; A J Paine
Journal: Biochem J Date: 1990-05-01 Impact factor: 3.857

3. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Authors: I U Schraufstatter; D B Hinshaw; P A Hyslop; R G Spragg; C G Cochrane
Journal: J Clin Invest Date: 1986-04 Impact factor: 14.808