Literature DB >> 6283825

Oxidative damage to lysosomal enzymes in human phagocytosing neutrophils.

R S Weening, A A Voetman, M N Hamers, L J Meerhof, A A Bot, D Roos.   

Abstract

During phagocytosis neutrophils from 8 patients with chronic granulomatous disease released 2-3 times more activity of lysozyme and beta-glucuronidase than did normal neutrophils. This difference was caused by the partial inactivation of these enzymes by normal neutrophils. The inactivation of granule enzymes depends on oxidative products and takes place mainly in the phagolysosomes. Myeloperoxidase is involved in this phenomenon.

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Year:  1982        PMID： 6283825     DOI： 10.1007/978-1-4684-8088-7_26

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  2 in total

1.  Opsonization of Staphylococcus aureus protects endothelial cells from damage by phagocytosing polymorphonuclear leukocytes.

Authors:  C M Vandenbroucke-Grauls; H M Thijssen; J Verhoef
Journal:  Infect Immun       Date:  1987-06       Impact factor: 3.441

2.  Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair.

Authors:  Cathelijn E M Aarts; Ida H Hiemstra; Eelke P Béguin; Arjan J Hoogendijk; Souhailla Bouchmal; Michel van Houdt; Anton T J Tool; Erik Mul; Machiel H Jansen; Hans Janssen; Floris P J van Alphen; Jan-Paul de Boer; Charlotte L Zuur; Alexander B Meijer; Timo K van den Berg; Taco W Kuijpers
Journal:  Blood Adv       Date:  2019-11-26
  2 in total

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