| Literature DB >> 6283496 |
D Bataille, C Gespach, K Tatemoto, J C Marie, A M Coudray, G Rosselin, V Mutt.
Abstract
A bioactive form of enteroglucagon has been isolated from porcine jejuno-ileum according to its glucagon-like effect in liver. Enzymatic digestion followed by HPLC, dansylation and partial sequence analysis strongly suggests that this peptide contains the glucagon molecule (1--29) elongated at the C-terminal end by the octapeptide Lys-Arg-Asn-Lys-Asn-Ile-Ala-COOH and possibly modified in the N-terminal region. A specific action of bioactive enteroglucagon, increase in cAMP, has been found in the acid-secreting fundic part of the rat stomach. The term "oxyntomodulin" is therefore proposed to describe this peptide.Entities:
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Year: 1981 PMID： 6283496 DOI： 10.1016/0196-9781(81)90008-5
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750