Literature DB >> 6283020

Role of neuronal signal input in the down-regulation of central noradrenergic receptor function by antidepressant drugs.

A Janowsky, L R Steranka, D D Gillespie, F Sulser.   

Abstract

Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down-regulation by antidepressants of the noradrenergic cyclic AMP-generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade of NE reuptake) reduced the cyclic AMP response to NE on the nonlesioned side, but had little or no effect on the lesioned side. The results indicate that NE signal input and thus the formation of the NE-receptor complex are prerequisites for inducing noradrenergic subsensitivity.

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Year:  1982        PMID： 6283020     DOI： 10.1111/j.1471-4159.1982.tb04739.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  9 in total

1.  Supersensitive beta-adrenergic receptors are down-regulated in rat brain by mianserin administration.

Authors:  A Pilc; S J Enna
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

2.  Molecular mechanisms in the action of imipramine.

Authors:  E Costa; D M Chuang; M L Barbaccia; O Gandolfi
Journal:  Experientia       Date:  1983-08-15

3.  Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model.

Authors:  S T Mason; A Angel
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  The serotonin/noradrenaline-link in brain. I. The role of noradrenaline and serotonin in the regulation of density and function of beta adrenoceptors and its alteration by desipramine.

Authors:  D H Manier; D D Gillespie; E Sanders-Bush; F Sulser
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-02       Impact factor: 3.000

5.  6-Hydroxydopamine pretreatment effects on alpha- and beta-adrenergic receptor adaptation to clorgyline.

Authors:  R M Cohen; C Aulakh; C McLellan; D L Murphy
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-04       Impact factor: 3.000

6.  Studies on rat brain catecholamine synthesis and beta-adrenoceptor number following administration of electroconvulsive shock, desipramine and clenbuterol.

Authors:  V L Nimgaonkar; D J Heal; C L Davies; A R Green
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

Review 7.  Neuroanatomical, Biochemical, and Functional Modifications in Brain Induced by Treatment with Antidepressants.

Authors:  Nikhat J Siddiqi; Maria de Lourdes Pereira; Bechan Sharma
Journal:  Mol Neurobiol       Date:  2022-03-29       Impact factor: 5.590

8.  A pivotal role for serotonin (5HT) in the regulation of beta adrenoceptors by antidepressants: reversibility of the action parachlorophenylalanine by 5-hydroxytroptophan.

Authors:  D H Manier; D D Gillespie; L R Steranka; F Sulser
Journal:  Experientia       Date:  1984-11-15

9.  Effect of selective monoamine oxidase inhibition by clorgyline and deprenyl on the norepinephrine receptor-coupled adenylate cyclase system in rat cortex.

Authors:  R Mishra; D D Gillespie; M B Youdim; F Sulser
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530
  9 in total

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