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Literature DB >> 6282577

Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.

T Damstra, W Jurgelski, H S Posner, V B Vouk, N J Bernheim, J Guthrie, M Luster, H L Falk.

Abstract

The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity, mutagenicity and carcinogenicity. The absorption, distribution, biotransformation and elimination of these polybrominated biphenyls are discussed along with the interactions with other chemicals and drugs.

Entities: Disease Species

Mesh：

Substances：

Year: 1982 PMID： 6282577 PMCID： PMC1568977 DOI： 10.1289/ehp.8244175

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

93 in total

Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.

1. Polybrominated biphenyls: tissue distribution and effect on hepatic microsomal enzymes in Japanese quail.

2. Variation of polybrominated biphenyl homolog peaks in blood of rats following treatment with Firemaster FF-1.

Review 3. Metabolic activation: biochemical basis for many drug-induced liver injuries.

4. Correlation of systemic and biochemical effects of PBB with behavioral effects.

5. Toxicologic assessments of a commercial polybrominated biphenyl mixture in the rat.

6. Effects of polybrominated biphenyl on a discrimination task in rats.

7. Field concentrations and persistence of polybrominated biphenyls in soils and solubility of PBB in natural waters.

8. EM changes and other toxic effects of firemaster BP-6 (polybrominated biphenyls) in the mouse.

9. Formation of brominated dibenzofurans from pyrolysis of the polybrominated biphenyl fire retardant, firemaster FF-1.

10. Responses of nonhuman primates to a polybrominated biphenyl mixture.

1. Dietary exposure to brominated flame retardants and abnormal Pap test results.

Review 2. The role of structure in the disposition of halogenated aromatic xenobiotics.