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Literature DB >> 6282120

Spin label electron paramagnetic resonance (EPR) studies of Huntington disease erythrocyte membranes.

Abstract

Several spin-label electron paramagnetic resonance (EPR) studies of red cell membranes appear to show abnormalities in some Huntington disease (HD) patients, but not in others. Both studies measure the W/S ratios, presumably under similar conditions, but have different results. We have studied the W/S ratio in some detail to gain a better understanding of this experimental parameter and to determine its potential application in detecting HD abnormalities. Our results offer little encouragement for continued use of W/S as an indication of membrane defect in HD.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Spin Labels

Year: 1982 PMID： 6282120 PMCID： PMC1685354

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

18 in total

1. Membrane fluidity and fatty acid composition of phospholipids in erythrocyte membranes of patients with Huntington disease.

Authors: M E Abood; M Butler
Journal: J Neurosci Res Date: 1979 Impact factor: 4.164

5. Electron spin resonance, hematological, and deformability studies of erythrocytes from patients with Huntington's disease.

Authors: D A Butterfield; M J Purdy; W R Markesbery
Journal: Biochim Biophys Acta Date: 1979-03-08

9. Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia.

Authors: E D Bird; L L Iversen
Journal: Brain Date: 1974-09 Impact factor: 13.501

Spin label electron paramagnetic resonance (EPR) studies of Huntington disease erythrocyte membranes.

1. Membrane fluidity and fatty acid composition of phospholipids in erythrocyte membranes of patients with Huntington disease.

2. Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease.

3. Electron spin resonance study of membrane protein alterations in erythrocytes in Huntington's disease.

4. Topology of a protein spin label in erythrocyte membranes.

5. Electron spin resonance, hematological, and deformability studies of erythrocytes from patients with Huntington's disease.

6. A study of the structural integrity of spin-labelled proteins in some fractions of human erythrocyte ghosts.

7. Huntington's chorea in the West of Scotland.

8. Social perspectives in Huntington's chorea.

9. Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia.

10. A simplification of the protein assay method of Lowry et al. which is more generally applicable.

1. Erythrocyte spectrin maintains its segmental motions on oxidation: a spin-label EPR study.

Review 2. The current state of research with peripheral tissues in Huntington disease.