Literature DB >> 6282020

Regulation of intracellular protein degradation by insulin and growth factors.

F J Ballard, M K Nield, G L Francis, S E Knowles.   

Abstract

Protein breakdown in many cell lines is inhibited by growth factors. The response is specific, rapid and additive only at suboptimal concentrations. Transformed cells are typically more sensitive to growth factors than nontransformed cells while the effectiveness of growth factors in human fibroblasts is diminished with senescence. Bovine colostrum has been shown to be an extremely rich source of growth factors as compared to serum.

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Year:  1981        PMID： 6282020

Source DB:  PubMed          Journal:  Acta Biol Med Ger        ISSN： 0001-5318


  3 in total

1.  Distinct proteolytic mechanisms in serum-sufficient and serum-restricted fibroblasts. Transformed 3T3 cells fail to regulate proteolysis in relation to culture density only during serum-sufficiency.

Authors:  S M Cockle; R T Dean
Journal:  Biochem J       Date:  1984-07-01       Impact factor: 3.857

2.  Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts.

Authors:  F J Ballard; L C Read; G L Francis; C J Bagley; J C Wallace
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

3.  Inhibition of protein breakdown by epidermal growth factor in IMR90 human fibroblasts and other mammalian cell lines.

Authors:  J M Gunn; J B Bodner; S E Knowles; F J Ballard
Journal:  Biochem J       Date:  1983-01-15       Impact factor: 3.857
  3 in total

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