Literature DB >> 6281887

Intracellular pH of mitogen-stimulated lymphocytes.

D F Gerson, H Kiefer, W Eufe.   

Abstract

Mitogenic stimulation of mouse lymphocytes results in two sequential intracellular alkalinizations. The first shift of intracellular pH from 7.18 to 7.35 coincides with early biochemical events following mitogenic stimulation. The second alkalinization begins 12 hours after stimulation and rises in parallel with the rate of thymidine incorporation. The results suggest that intracellular alkalinization following stimulation may play a key role in the enhancement of cellular activation and mitogenesis.

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Year:  1982        PMID： 6281887     DOI： 10.1126/science.6281887

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

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