Literature DB >> 6280774

Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin.

J V Bannister, W H Bannister, H A Hill, P J Thornalley.   

Abstract

The generation of hydroxyl radicals by the xanthine-xanthine oxidase reaction (C. Beauchamp and I. Fridovich (1970) J. Biol. Chem. 245, 4641-1616) has been shown to be increased by iron-saturated lactoferrin isolated from pig neutrophils. Hydroxyl radical production, measured by EPR spin trapping and by ethylene production from alpha-keto-gamma-methiol butyric acid, has been demonstrated to be produced by a Fenton-type Haber-Weiss reaction catalysed by lactoferrin. The possibility that lactoferrin catalyses such a reaction in vivo is considered.

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Year:  1982        PMID： 6280774     DOI： 10.1016/0304-4165(82)90056-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  12 in total

Review 1.  Oxygen toxicity, oxygen radicals, transition metals and disease.

Authors:  B Halliwell; J M Gutteridge
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857

2.  Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

3.  Myeloperoxidase as an effective inhibitor of hydroxyl radical production. Implications for the oxidative reactions of neutrophils.

Authors:  C C Winterbourn
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

4.  Neutrophil degranulation inhibits potential hydroxyl-radical formation. Relative impact of myeloperoxidase and lactoferrin release on hydroxyl-radical production by iron-supplemented neutrophils assessed by spin-trapping techniques.

Authors:  B E Britigan; D J Hassett; G M Rosen; D R Hamill; M S Cohen
Journal:  Biochem J       Date:  1989-12-01       Impact factor: 3.857

5.  Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

Authors:  P Biemond; H G van Eijk; A J Swaak; J F Koster
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808

6.  Pseudomonas and neutrophil products modify transferrin and lactoferrin to create conditions that favor hydroxyl radical formation.

Authors:  B E Britigan; B L Edeker
Journal:  J Clin Invest       Date:  1991-10       Impact factor: 14.808

7.  Lactoferrin stimulates the production of leucocyte migration inhibitory factor by human peripheral mononuclear leucocytes.

Authors:  A Kijlstra; L Broersma
Journal:  Clin Exp Immunol       Date:  1984-02       Impact factor: 4.330

8.  Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice.

Authors:  Pauline P Ward; Marisela Mendoza-Meneses; Pyong W Park; Orla M Conneely
Journal:  Am J Pathol       Date:  2008-03-05       Impact factor: 4.307

9.  Prooxidant activity of transferrin and lactoferrin.

Authors:  S J Klebanoff; A M Waltersdorph
Journal:  J Exp Med       Date:  1990-11-01       Impact factor: 14.307

Review 10.  The role of oxygen free radicals in occupational and environmental lung diseases.

Authors:  V Vallyathan; X Shi
Journal:  Environ Health Perspect       Date:  1997-02       Impact factor: 9.031
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