Literature DB >> 6280352

Fast hardening aminoacid-solution as potential carrier of chemotherapeutic agents in the treatment of chronic osteomyelitis.

K H Schultheis, A Schulz, H G Schiefer.   

Abstract

Report about an aminoacid, which hardens quickly in liquid environment. It is highly suitable as carrier of chemotherapeutic agents. In-vitro tests show an antibiotic inhibitory activity of different compounds for at least 41 days. According to in-vivo experiments in 17 rats the new substance is replaced in the bone and in soft tissues by fibrous tissue; the antibiotic activity is released slowly. This offers a new carrier which is suitable for occlusion of cavities. The instillation of the new amino-acid (Ethibloc) combined with antibiotics could be a new treatment for chronic osteomyelitis.

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Year:  1981        PMID： 6280352     DOI： 10.1007/bf02592973

Source DB:  PubMed          Journal:  Unfallchirurgie        ISSN： 0340-2649


  5 in total

1.  [Results of treatment following plastic surgery technics in chronic osteomyelitis. A 19-year series].

Authors:  H Ecke; R Bernstein; J Kyambi
Journal:  Monatsschr Unfallheilkd Versicher Versorg Verkehrsmed       Date:  1974-01

2.  [Indication and use of Septopal in chronic osteitis (author's transl)].

Authors:  K Weise; S Weller
Journal:  Aktuelle Traumatol       Date:  1980-04

3.  [Treatment of soft tissue infections with gentamycin-polymethylmethacrylate bead chains].

Authors:  A Härle
Journal:  Chirurg       Date:  1980-11       Impact factor: 0.955

4.  [Gentamycin resistance of gram negative bacteria in clinical materials].

Authors:  R Baier; H Puppel
Journal:  Ther Ggw       Date:  1981-02

5.  [Occlusion of pancreatic duct system by injection of a fast-solidifying amino acid solution (author's transl)].

Authors:  C Gebhardt; M Stolte
Journal:  Langenbecks Arch Chir       Date:  1978-10-16
  5 in total
  2 in total

1.  [Release delay of various antibiotics from resorbable tricalcium phosphate ceramic granules with soluble coating for local treatment of osteomyelitis. An animal experiment study].

Authors:  J Eitenmüller; G Peters; W Golsong; R Weltin; G Gellissen; W Reichmann
Journal:  Langenbecks Arch Chir       Date:  1983

2.  Experimental evaluation of a percutaneous injectable biomaterial used in radio-interventional bone-filling procedures.

Authors:  G Pasquier; B Flautre; H Leclet; P Hardouin
Journal:  J Mater Sci Mater Med       Date:  1998-06       Impact factor: 3.896
  2 in total

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