| Literature DB >> 6280005 |
C C Tsang, K V Speeg, G R Wilkinson.
Abstract
The specific binding of 3H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fisher-344 rats. No age-related differences in the association, equilibrium, or dissociation, binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex.Entities:
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Year: 1982 PMID： 6280005 DOI： 10.1016/0024-3205(82)90570-7
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037