Literature DB >> 627814

Precocious 'feminization' of rat liver enzymes in the presence of ectopic pituitary tissue.

J Gustafsson, P Skett.   

Abstract

The presence of ectopic pituitary tissue (derived from an adult rat) in prepubertal male and female rats caused the immature, masculine-type hepatic steroid metabolism to develop into female-type metabolism. It is concluded that the hypothalamus-pituitary system controls the ontogenesis of sex-dependent steroid metabolism in rat liver.

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Year:  1978        PMID: 627814     DOI: 10.1677/joe.0.0760187

Source DB:  PubMed          Journal:  J Endocrinol        ISSN: 0022-0795            Impact factor:   4.286


  1 in total

1.  Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents.

Authors:  J A Gustafsson; P Eneroth; T Hökfelt; A Mode; G Norstedt; P Skett
Journal:  Environ Health Perspect       Date:  1981-04       Impact factor: 9.031

  1 in total

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