| Literature DB >> 6277696 |
D Abrutyn, B E McKenzie, N Nadaskay.
Abstract
Pregnant Long-Evans Hooded rats were intravaginally administered nonoxynol-9, a non-ionic surfactant used as a spermicidal agent in Delfen Contraceptive Cream (Ortho Pharmaceutical Corporation, Raritan, N.J.) at dosages of 4 or 40 mg/kg/day (2 and 20 times the clinical usage) on days 6 through 15 of gestation. Untreated, vehicle and sham control groups were also incorporated into the study protocol. No meaningful differences were observed between the treated and control groups in maternal toxicity, gross and microscopic appearance of vagina, maternal reproductive parameters, fetal toxicity, and the incidence of visceral and skeletal malformations.Entities:
Keywords: Alcohols; Animals, Laboratory; Biology; Body Weight; Clinical Research; Congenital Abnormalities; Contraception; Contraceptive Agents; Contraceptive Methods--administraction and dosage; Diseases; Family Planning; Incidence; Ingredients And Chemicals; Measurement; Neonatal Diseases And Abnormalities; Nonoxynol--administraction and dosage; Organic Chemicals; Physiology; Research Methodology; Spermicidal Contraceptive Agents; Vaginal Cream--administraction and dosage; Vaginal Spermicides--administraction and dosage
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Year: 1982 PMID： 6277696 DOI： 10.1016/s0015-0282(16)45988-1
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329