Literature DB >> 6277663

Age-related decrease of in vitro isoproterenol-induced cyclic AMP accumulation in rat aorta.

P Schoeffter, J C Stoclet.   

Abstract

Isoproterenol-induced accumulation of cyclic AMP was investigated in aorta rings from 7 to 18 weeks old rats. The effect of isoproterenol on cyclic AMP reached a maximum in 1 min. The concentration-effect curves showed a significant decrease of the maximal accumulation of cyclic AMP as a function of age, without any variation in the effective concentration range. These results parallel the previously reported decrease of beta-adrenergic relaxation of rat aorta with age.

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Year:  1982        PMID： 6277663     DOI： 10.1016/0014-2999(82)90017-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP.

Authors:  M Boese; R Busse; A Mülsch; V Schini-Kerth
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

2.  Dissociation between endothelium-mediated increases in tissue cGMP levels and modulation of aortic contractile responses.

Authors:  M Bigaud; P Schoeffter; J C Stoclet; R C Miller
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-12       Impact factor: 3.000

Review 3.  Age-related changes in vascular smooth muscle and endothelium.

Authors:  Y Dohi; M Kojima; K Sato; T F Lüscher
Journal:  Drugs Aging       Date:  1995-10       Impact factor: 3.923

4.  Endothelial mediated inhibition of contraction and increase in cyclic GMP levels evoked by the alpha-adrenoceptor agonist B-HT 920 in rat isolated aorta.

Authors:  R C Miller; M Mony; V Schini; P Schoeffter; J C Stoclet
Journal:  Br J Pharmacol       Date:  1984-12       Impact factor: 8.739

5.  Age-associated decrease in histamine-induced vasodilation may be due to reduction of cyclic GMP formation.

Authors:  H Moritoki; A Tanioka; Y Maeshiba; T Iwamoto; Y Ishida; H Araki
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

6.  Insensitivity of calcium-dependent endothelial stimulation in rat isolated aorta to the calcium entry blocker, flunarizine.

Authors:  R C Miller; P Schoeffter; J C Stoclet
Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739

7.  Age-related changes in adenosine and beta-adrenoceptor responsiveness of vascular smooth muscle in man.

Authors:  G A Ford; B B Hoffman; R E Vestal; T F Blaschke
Journal:  Br J Clin Pharmacol       Date:  1992-01       Impact factor: 4.335
  7 in total

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