Literature DB >> 6277498

Glucocorticoid regulation of the Ha-MuSV p21 gene conferred by sequences from mouse mammary tumor virus.

A L Huang, M C Ostrowski, D Berard, G L Hager.   

Abstract

Molecular chimeras with the p21 transforming gene of Harvey murine sarcoma virus linked to DNA containing the long terminal repeat (LTR) or mouse mammary tumor virus (MMTV) have been constructed. Transformants of NIH 3T3 cells induced by transfection with MMTV LTR-p21 hybrid DNA have been identified that express the normal p21 gene product. The levels of p21 RNA and protein in these transformants are regulated by physiological concentrations of dexamethasone, a synthetic glucocorticoid hormone. Hybrid transcripts containing p21 gene sequences originate at the normal MMTV viral initiation site. It is concluded that sequences necessary for hormonal control of transcription are completely specified by the viral genome and probably map within the viral LTR.

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Year:  1981        PMID： 6277498     DOI： 10.1016/0092-8674(81)90408-6

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  111 in total

1.  Mutations in the hormone regulatory element of mouse mammary tumor virus differentially affect the response to progestins, androgens, and glucocorticoids.

Authors:  P L Gowland; E Buetti
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

2.  Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues.

Authors:  M Ballin; A R Mackay; J L Hartzler; A Nason; M D Pelina; U P Thorgeirsson
Journal:  Clin Exp Metastasis       Date:  1991 Mar-Apr       Impact factor: 5.150

3.  Independent glucocorticoid induction and repression of two contiguous responsive genes.

Authors:  J Charron; H Richard-Foy; D S Berard; G L Hager; J Drouin
Journal:  Mol Cell Biol       Date:  1989-07       Impact factor: 4.272

4.  Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo.

Authors:  Rainer B Lanz; Steven S Chua; Niall Barron; Bettina M Söder; Francesco DeMayo; Bert W O'Malley
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

5.  Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.

Authors:  P H Hand; A Thor; D Wunderlich; R Muraro; A Caruso; J Schlom
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

6.  Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

Authors:  D M Ornitz; R W Moreadith; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

7.  Glucocorticoid and progestin receptors are differently involved in the cooperation with a structural element of the mouse mammary tumor virus promoter.

Authors:  S Le Ricousse; F Gouilleux; D Fortin; V Joulin; H Richard-Foy
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

8.  Asymmetric transcription of mouse mammary tumor virus genes in vivo and in vitro.

Authors:  R S Prewitt; L D Washington; M R Stallcup
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

9.  Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.

Authors:  S C Supowit; E Potter; R M Evans; M G Rosenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

10.  Increased concentration of an indigenous proviral mouse mammary tumor virus long terminal repeat-containing transcript is associated with neoplastic transformation of mammary epithelium in C3H/Sm mice.

Authors:  D E Graham; D Medina; G H Smith
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103
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