Literature DB >> 6277471

Carcinogenicity in rats of the mutagenic compounds 1-nitropyrene and 3-nitrofluoranthene.

H Ohgaki, N Matsukura, K Morino, T Kawachi, T Sugimura, K Morita, H Tokiwa, T Hirota.   

Abstract

1-Nitropyrene and 3-nitrofluoranthene are present in diesel exhaust, in pollutants in air, and were also present in certain xerographic toners and copies. Their carcinogenicities were studied in male F344/DuCrj rats by subcutaneous injection. Sarcomas, mainly malignant fibrous histiocytomas at the site of injection were induced in 8 to 17 (47%) rats by 1-nitropyrene and in 4 of 10 (40%) rats by 3-nitrofluoranthene. Some tumors were serially transplantable in the same strain of rats.

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Year:  1982        PMID： 6277471     DOI： 10.1016/0304-3835(82)90068-4

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  7 in total

1.  Studies on comparative decomposition rate by rat liver homogenate and on micronucleus test of nitrated polycyclic aromatic hydrocarbons.

Authors:  T Ohe
Journal:  Bull Environ Contam Toxicol       Date:  1985-05       Impact factor: 2.151

2.  Biodegradation of 1-nitropyrene.

Authors:  M A Heitkamp; J P Freeman; D W Miller; C E Cerniglia
Journal:  Arch Microbiol       Date:  1991       Impact factor: 2.552

3.  Fungal metabolism and detoxification of the nitropolycyclic aromatic hydrocarbon 1-nitropyrene.

Authors:  C E Cerniglia; J P Freeman; G L White; R H Heflich; D W Miller
Journal:  Appl Environ Microbiol       Date:  1985-09       Impact factor: 4.792

4.  Purification and characterization of 1-nitropyrene nitroreductases from Bacteroides fragilis.

Authors:  T Kinouchi; Y Ohnishi
Journal:  Appl Environ Microbiol       Date:  1983-09       Impact factor: 4.792

5.  Nitroaromatic carcinogens in diesel soot: a review of laboratory findings.

Authors:  E T Wei; H P Shu
Journal:  Am J Public Health       Date:  1983-09       Impact factor: 9.308

6.  In vitro characterization of DNA adducts formed by foundry air particulate matter.

Authors:  K Savela; M J Kohan; D Walsh; F P Perera; K Hemminki; J Lewtas
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031

Review 7.  Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment.

Authors:  D Krewski; J R Withey; L F Ku; M E Andersen
Journal:  Environ Health Perspect       Date:  1994-12       Impact factor: 9.031
  7 in total

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