Literature DB >> 6275947

Analgesic dipeptide, kyotorphin (Tyr-Arg), is highly concentrated in the synaptosomal fraction of the rat brain.

H Ueda, K Tatsumi, H Shiomi, H Takagi.   

Abstract

To examine the physiological role of the analgesic dipeptide, kyotorphin (Tyr-Arg), which was isolated from the mammalian brain, its subcellular localization was studied. Kyotorphin was determined using high-performance liquid chromatography (HPLC) with an electrochemical detector. This dipeptide was found to be concentrated in the crude mitochondrial (P2) fraction. Further subfractionation of the P2 fraction revealed that kyotorphin was exclusively localized in the synaptosomal fraction.This finding suggests the possibility that kyotorphin has a neurotransmitter/neuromodulator role in the brain.

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Year:  1982        PMID： 6275947     DOI： 10.1016/0006-8993(82)90023-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes.

Authors:  Jianming Xiang; Huidi Jiang; Yongjun Hu; David E Smith; Richard F Keep
Journal:  Brain Res       Date:  2010-06-09       Impact factor: 3.252

2.  Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice.

Authors:  Huidi Jiang; Yongjun Hu; Richard F Keep; David E Smith
Journal:  J Neurochem       Date:  2009-04-04       Impact factor: 5.372

3.  L-leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia.

Authors:  A Kawabata; Y Nishimura; H Takagi
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

4.  A novel method for the synthesis of kyotorphin, Tyr-Arg, and 3H-Tyr-Arg, catalyzed by tyrosyl-tRNA synthetase from Bacillus stearothermophilus.

Authors:  S Kitabatake; R Tsurutani; H Nakajima; K Tomita; Y Yoshihara; H Ueda; H Takagi; K Imahori
Journal:  Pharm Res       Date:  1987-04       Impact factor: 4.200

5.  Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer's Disease Patients: Potential Diagnostic and Pharmacological Implications.

Authors:  Sara Matos Santos; Laura Garcia-Nimo; Sónia Sá Santos; Isaura Tavares; José A Cocho; Miguel A R B Castanho
Journal:  Front Aging Neurosci       Date:  2013-10-30       Impact factor: 5.750

6.  The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.

Authors:  Rita F Belo; Margarida L F Martins; Liana Shvachiy; Tiago Costa-Coelho; Carolina de Almeida-Borlido; João Fonseca-Gomes; Vera Neves; Hugo Vicente Miranda; Tiago F Outeiro; Joana E Coelho; Sara Xapelli; Cláudia A Valente; Montserrat Heras; Eduard Bardaji; Miguel A R B Castanho; Maria José Diógenes; Ana M Sebastião
Journal:  Front Pharmacol       Date:  2020-07-09       Impact factor: 5.810

Review 7.  Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics.

Authors:  Hiroshi Ueda
Journal:  Front Med Technol       Date:  2021-04-01
  7 in total

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