Literature DB >> 6275367

Nucleotide sequence of the transforming early region E1b of adenovirus type 12 DNA: structure and gene organization, and comparison with those of adenovirus type 5 DNA.

T Kimura, Y Sawada, M Shinawawa, Y Shimizu, K Shiroki, H Shimojo, H Sugisaki, M Takanami, Y Uemizu, K Fujinaga.   

Abstract

The nucleotide sequence of the entire transforming early region of E1b of the highly oncogenic adenovirus type 12 (Ad12) DNA has been determined. The total sequence (3860 base pairs) encompasses the entire transforming early region E1 of Ad12 DNA. From the sequence for the E1b region of Ad12, and the transcription map of the E1b region (1, 2, 3, and this paper) the structure and gene organization of the early region E1b of Ad12 DNA were analyzed and compared with those of the E1b region in the non-oncogenic Ad5 DNA (4, 5). Most of the sequences in the E1b region of Ad12 was highly homologous to that of Ad5. It is predicted that the Ad12 region E1b codes for polypeptides of 53.9, 19.1, and 8.9 kd. This situation is identical with that of the Ad5 region E1b which codes for polypeptides of 54.9, 20.6, and 8.3 kd. The function of these predicted polypeptides encoded by the E1b regions in cell transformation is discussed.

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Year:  1981        PMID： 6275367      PMCID： PMC327623          DOI： 10.1093/nar/9.23.6571

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  37 in total

1.  Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone.

Authors:  P H Seeburg; J Shine; J A Martial; J D Baxter; H M Goodman
Journal:  Nature       Date:  1977-12-08       Impact factor: 49.962

2.  Thirty-one human adenovirus serotypes (Ad1-Ad31) form five groups (A-E) based upon DNA genome homologies.

Authors:  M Green; J K Mackey; W S Wold; P Rigden
Journal:  Virology       Date:  1979-03       Impact factor: 3.616

3.  Proteins and messenger RNAs of the transforming region of wild-type and mutant adenoviruses.

Authors:  H Esche; M B Mathews; J B Lewis
Journal:  J Mol Biol       Date:  1980-09-25       Impact factor: 5.469

4.  The 3'-Terminal nucleotide sequence of encephalomyocarditis virus RNA.

Authors:  J Merregaert; J van Emmelo; R Devos; A Porter; P Fellner; W Fiers
Journal:  Eur J Biochem       Date:  1978-01-02

5.  Biogenesis, structures, and sites of encoding of the 5' termini of adenovirus-2 mRNAs.

Authors:  C C Baker; E B Ziff
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1980

6.  Comparison of nucleotide sequences of the early E1a regions for subgroups A, B and C of human adenoviruses.

Authors:  H van Ormondt; J Maat; R Dijkema
Journal:  Gene       Date:  1980-12       Impact factor: 3.688

7.  Identification and mapping of the early gene products of adenovirus type 12.

Authors:  H Jochemsen; G S Daniels; J H Lupker; A J van der Eb
Journal:  Virology       Date:  1980-09       Impact factor: 3.616

8.  Identification of families of overlapping polypeptides coded by early "transforming" gene region 1 of human adenovirus type 2.

Authors:  M Green; W S Wold; K H Brackmann; M A Cartas
Journal:  Virology       Date:  1979-09       Impact factor: 3.616

9.  The gene for polypeptide IX of adenovirus type 2 and its unspliced messenger RNA.

Authors:  P Aleström; G Akusjärvi; M Perricaudet; M B Mathews; D F Klessig; U Pettersson
Journal:  Cell       Date:  1980-03       Impact factor: 41.582

10.  Structure of two adenovirus type 12 transforming polypeptides and their evolutionary implications.

Authors:  M Perricaudet; J M le Moullec; P Tiollais; U Pettersson
Journal:  Nature       Date:  1980-11-13       Impact factor: 49.962
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  16 in total

1.  Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.

Authors:  M F Kagnoff; Y J Paterson; P J Kumar; D D Kasarda; F R Carbone; D J Unsworth; R K Austin
Journal:  Gut       Date:  1987-08       Impact factor: 23.059

Review 2.  Expression and interactions of human adenovirus oncoproteins.

Authors:  P A Boulanger; G E Blair
Journal:  Biochem J       Date:  1991-04-15       Impact factor: 3.857

3.  Structure of viral DNA in a rat cell line transformed by the cloned EcoRI-C fragment of adenovirus 12.

Authors:  Y Kawarabayasi; H Sugisaki
Journal:  Nucleic Acids Res       Date:  1985-09-25       Impact factor: 16.971

Review 4.  The structure and functions of the adenovirus early region 1 proteins.

Authors:  R J Grand
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

5.  Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis.

Authors:  J Sprengel; B Schmitz; D Heuss-Neitzel; C Zock; W Doerfler
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103

6.  Isolation of transformation-defective, replication-nondefective early region 1B mutants of adenovirus 12.

Authors:  Y Fukui; I Saito; K Shiroki; H Shimojo
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

7.  Characterization of a host range mutant of human adenovirus 12 defective in early region 1B.

Authors:  Y Fukui; K Shiroki; I Saito; H Shimojo
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

8.  Insertion of adenovirus type 12 DNA in the vicinity of an intracisternal A particle genome in Syrian hamster tumor cells.

Authors:  U Lichtenberg; C Zock; W Doerfler
Journal:  J Virol       Date:  1987-09       Impact factor: 5.103

9.  Expression of the chloramphenicol acetyltransferase gene in mammalian cells under the control of adenovirus type 12 promoters: effect of promoter methylation on gene expression.

Authors:  I Kruczek; W Doerfler
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

10.  Human adenovirus 2 E1B-19K and E1B-53K tumor antigens: antipeptide antibodies targeted to the NH2 and COOH termini.

Authors:  M Green; K H Brackmann; L A Lucher; J S Symington; T A Kramer
Journal:  J Virol       Date:  1983-12       Impact factor: 5.103
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