Literature DB >> 627520

A32390A, a new biologically active metabolite. II. Isolation and structure.

G G Marconi, B B Molloy, R Nagarajan, J W Martin, J B Deeter, J L Occolowitz.   

Abstract

An inhibitor of dopamine-beta-hydroxylase, designated A32390A, was isolated from the culture broth of a Pyrenochaeta species. The inhibitor showed antimicrobial activity against fungi and gram-positive bacteria. Spectroscopic analysis and chemical degradation studies indicated that the structure was 1,6-di-O-(2-isocyano-3-methylcrotonyl)-D-mannitol.

Entities:  

Mesh:

Substances:

Year:  1978        PMID: 627520     DOI: 10.7164/antibiotics.31.27

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  3 in total

1.  Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus.

Authors:  Dexter C Davis; Haroon Mohammad; Kwaku Kyei-Baffour; Waleed Younis; Cassidy Noel Creemer; Mohamed N Seleem; Mingji Dai
Journal:  Eur J Med Chem       Date:  2015-06-16       Impact factor: 6.514

2.  Treponemycin, a nitrile antibiotic active against Treponema hyodysenteriae.

Authors:  S K Singh; S Gurusiddaiah; J W Whalen
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

3.  Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi.

Authors:  Tae Hyung Won; Jin Woo Bok; Nischala Nadig; Nandhitha Venkatesh; Grant Nickles; Claudio Greco; Fang Yun Lim; Jennifer B González; B Gillian Turgeon; Nancy P Keller; Frank C Schroeder
Journal:  Nat Commun       Date:  2022-08-16       Impact factor: 17.694

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.