Literature DB >> 6274993

Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody.

M Robert-Guroff, F W Ruscetti, L E Posner, B J Poiesz, R C Gallo.   

Abstract

A monoclonal antibody specific for the internal p19 protein of a type-C retrovirus (HTLV) isolated from human neoplastic T cells has been developed. Its specificity has been shown by radioimmune precipitation and by affinity chromatography of iodinated HTLV proteins. By indirect immune fluorescence this antibody recognizes only HTLV-producing cells. Examination of cells from patients with cutaneous T cell lymphomas and leukemias and with other types of lymphomas and leukemias indicated that HTLV p19 expression is rare. The monoclonal antibody will be useful in determining the natural reservoir of HTLV, possibly in a subset of mature T cell neoplasias.

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Year:  1981        PMID： 6274993      PMCID： PMC2186543          DOI： 10.1084/jem.154.6.1957

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  11 in total

1.  Enhanced induction of growth of B lymphoblasts from fresh human blood by primate type-C retroviruses (gibbon ape leukemia virus and simian sarcoma virus).

Authors:  P D Markham; F Ruscetti; S Z Salahuddin; R E Gallagher; R C Gallo
Journal:  Int J Cancer       Date:  1979-02       Impact factor: 7.396

2.  Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

Authors:  P L Ey; S J Prowse; C R Jenkin
Journal:  Immunochemistry       Date:  1978-07

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line.

Authors:  H M Rho; B Poiesz; F W Ruscetti; R C Gallo
Journal:  Virology       Date:  1981-07-15       Impact factor: 3.616

5.  Antibodies to major histocompatibility antigens produced by hybrid cell lines.

Authors:  G Galfre; S C Howe; C Milstein; G W Butcher; J C Howard
Journal:  Nature       Date:  1977-04-07       Impact factor: 49.962

6.  Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines.

Authors:  G Köhler; S C Howe; C Milstein
Journal:  Eur J Immunol       Date:  1976-04       Impact factor: 5.532

7.  Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses.

Authors:  V S Kalyanaraman; M G Sarngadharan; B Poiesz; F W Ruscetti; R C Gallo
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

8.  Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes.

Authors:  M S Reitz; B J Poiesz; F W Ruscetti; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

9.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors:  B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

10.  Natural antibodies to the human T cell lymphoma virus in patients with cutaneous T cell lymphomas.

Authors:  L E Posner; M Robert-Guroff; V S Kalyanaraman; B J Poiesz; F W Ruscetti; B Fossieck; P A Bunn; J D Minna; R C Gallo
Journal:  J Exp Med       Date:  1981-08-01       Impact factor: 14.307
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  50 in total

1.  Primary isolation of human T-cell leukemia-lymphoma virus types I and II: use for confirming infection in seroindeterminate blood donors.

Authors:  B Hjelle; R Mills; C Goldsmith; S G Swenson; S Cyrus
Journal:  J Clin Microbiol       Date:  1992-08       Impact factor: 5.948

2.  Temporal regulation of viral and cellular gene expression during human T-lymphotropic virus type I-mediated lymphocyte immortalization.

Authors:  J T Kimata; L Ratner
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

3.  Effect of human T lymphotropic retrovirus-I exposure on cultured human glioma cell lines.

Authors:  B Macchi; B Caronti; M Pezzella; E Bonmassar; G Lauro
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

Review 4.  Ontogeny of the human thymus during fetal development.

Authors:  D F Lobach; B F Haynes
Journal:  J Clin Immunol       Date:  1987-03       Impact factor: 8.317

5.  Differential response to the cytopathic effects of human T-cell lymphotropic virus type III (HTLV-III) superinfection in T4+ (helper) and T8+ (suppressor) T-cell clones transformed by HTLV-I.

Authors:  A De Rossi; G Franchini; A Aldovini; A Del Mistro; L Chieco-Bianchi; R C Gallo; F Wong-Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

Review 6.  T-cell control by human T-cell leukemia/lymphoma virus type 1.

Authors:  Genoveffa Franchini; Risaku Fukumoto; Jake R Fullen
Journal:  Int J Hematol       Date:  2003-11       Impact factor: 2.490

7.  Molecular cloning of a unique human T-cell leukemia virus (HTLV-IIMo).

Authors:  E P Gelmann; G Franchini; V Manzari; F Wong-Staal; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

8.  Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

Authors:  M Yoshida; M Seiki; K Yamaguchi; K Takatsuki
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

9.  Human T-cell leukemia virus-associated membrane antigens: identity of the major antigens recognized after virus infection.

Authors:  T H Lee; J E Coligan; T Homma; M F McLane; N Tachibana; M Essex
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

10.  Protective effect of interferon beta on human T cell leukaemia virus type I infection of CD4+ T cells isolated from human cord blood.

Authors:  B Macchi; I Faraoni; A Mastino; C D'Onofrio; G Romeo; E Bonmassar
Journal:  Cancer Immunol Immunother       Date:  1993-07       Impact factor: 6.968
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