Literature DB >> 6274960

Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.

H J Showell, P H Naccache, P Borgeat, S Picard, P Vallerand, E L Becker, R I Sha'afi.   

Abstract

We have described in det ail the secretory activity of leukotriene B4 toward rabbit neutrophils. Leukotriene B4 rapidly and vigorously degranulates rabbit neutrophils. This activity is stereospecific, cytochalasin B-dependent, and is enhanced by extracellular calcium. Pretreatment with leukotriene B4 deactivates rabbit neutrophils, i.e., cells so treated do not respond to stimulation by an additional bolus of leukotriene B4. In addition, the secretory activity of leukotriene B4 is sharply dependent on the simultaneous presence of cytochalasin B. Rabbit neutrophils therefore exhibit the previously described desensitization to the effect of cytochalasin B. In these and other discussed respects the characteristics of the leukotriene B4-induced degranulation of rabbit neutrophils are strikingly similar to those of the chemotactic factors. These results support the hypothesis that leukotriene B4 mediates, at least in part, the secretory, and possibly other, activities of chemotactic factors.

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Year:  1982        PMID： 6274960

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  19 in total

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Authors:  M M Barrowman; S Cockcroft; B D Gomperts
Journal:  J Physiol       Date:  1987-02       Impact factor: 5.182

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Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

Review 3.  Leukotrienes in inflammation.

Authors:  M A Bray
Journal:  Agents Actions       Date:  1986-10

4.  Stimulated release of neutral proteinases elastase and cathepsin G from inflammatory rat polymorphonuclear leukocytes.

Authors:  M A Bray; C McKearn-Smith; G Metz-Virca; J L Bodmer; G D Virca
Journal:  Inflammation       Date:  1987-03       Impact factor: 4.092

5.  The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites.

Authors:  K A Haines; K N Giedd; A M Rich; H M Korchak; G Weissmann
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

6.  Macrophages cultured in vitro release leukotriene B4 and neutrophil attractant/activation protein (interleukin 8) sequentially in response to stimulation with lipopolysaccharide and zymosan.

Authors:  J A Rankin; I Sylvester; S Smith; T Yoshimura; E J Leonard
Journal:  J Clin Invest       Date:  1990-11       Impact factor: 14.808

7.  Leukotrienes stimulate insulin release from the rat pancreas.

Authors:  S B Pek; M F Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

8.  The in vivo effect of leukotriene B4 on polymorphonuclear leukocytes and the microcirculation. Comparison with activated complement (C5a des Arg) and enhancement by prostaglandin E2.

Authors:  H Z Movat; C Rettl; C E Burrowes; M G Johnston
Journal:  Am J Pathol       Date:  1984-05       Impact factor: 4.307

9.  Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression.

Authors:  S L Kunkel; S W Chensue; M Plewa; G I Higashi
Journal:  Am J Pathol       Date:  1984-02       Impact factor: 4.307

10.  Activation of the human neutrophil secretory process with 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid.

Authors:  R J Smith; S S Iden; B J Bowman
Journal:  Inflammation       Date:  1984-12       Impact factor: 4.092
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