The effect of indomethacin on renal blood flow and uretral pressure in unilateral ureteral obstruction in a awake dogs.

In the conscious dog, the effect of administering indomethacin before and throughout an 8-hr period of unilateral ureteral occlusion was determined. Before ureteral occlusion, indomethacin infusion caused a 35 to 40 per cent decrease in bilateral renal blood flow. After ureteral occulsion, the characteristic ipsilateral renal vasodilation did not occur and the ureteral pressure rose only to a maximum of 18 mm Hg and remained significantly lower (P less than 0.05) than pressures in control animals during the entire study period. Hence, pathways for renal synthesis of prostalglandins must be intact for renal vasodilation to occur in response to ureteral occlusion.