Literature DB >> 6274680

The brachymorphic mutation of mice and altered developmental patterns of limb bud 3':5' cyclic adenosine monophosphate.

D Hindin, R P Erickson.   

Abstract

Concentrations of cyclic AMP (cAMP) were determined in paired fore and hind limbs from day 12-16 of development in murine fetuses homozygous for the brachymorphic (bm) mutation and normal controls. A developmental rise in cAMP occurred 1 day earlier in bm/bm than in +/+ hind limbs and cAMP was higher in day-13 bm/bm than in +/+ fore limbs. Since cAMP is well documented to stimulate chondrogenic differentiation, premature cartilage determination secondary to altered levels of cAMP could play a role in bm/bm short-limbed dwarfism.

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Year:  1981        PMID： 6274680     DOI： 10.1007/bf01989888

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Undersulfated chondroitin sulfate in the cartilage matrix of brachymorphic mice.

Authors:  R W Orkin; R M Pratt; G R Martin
Journal:  Dev Biol       Date:  1976-05       Impact factor: 3.582

2.  Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice.

Authors:  K Sugahara; N B Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

3.  Cyclic 3' ,5'-AMP changes in chondrocytes of the proteoglycan-deficient chick embryonic mutant, nanomelia.

Authors:  L A Bourret; P F Goetinck; R Hintz; G A Rodan
Journal:  FEBS Lett       Date:  1979-12-15       Impact factor: 4.124

4.  A tissue culture analysis of the steps in limb chondrogenesis.

Authors:  M Solursh; P B Ahrens; R S Reiter
Journal:  In Vitro       Date:  1978-01

5.  Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides.

Authors:  A L Steiner; C W Parker; D M Kipnis
Journal:  J Biol Chem       Date:  1972-02-25       Impact factor: 5.157

6.  Cyclic AMP derivatives stimulate the chondrogenic differentiation of the mesoderm subjacent to the apical ectodermal ridge of the chick limb bud.

Authors:  R A Kosher; M P Savage; S C Chan
Journal:  J Exp Zool       Date:  1979-08

7.  Long acting cAMP analogues enhance sulfate incorporation into matrix proteoglycans and suppress cell division of fetal rat chondrocytes in monolayer culture.

Authors:  R P Miller; M Husain; S Lohin
Journal:  J Cell Physiol       Date:  1979-07       Impact factor: 6.384

8.  The effect of prostaglandins on ox pituitary content of adenosine 3':5'-cyclic monophosphate and the release of growth hormone.

Authors:  R H Cooper; M McPherson; J G Schofield
Journal:  Biochem J       Date:  1972-03       Impact factor: 3.857

9.  Cortisone-induced cleft palate in the brachymorphic mouse.

Authors:  R M Pratt; D S Salomon; V M Diewert; R P Erickson; R Burns; K S Brown
Journal:  Teratog Carcinog Mutagen       Date:  1980

10.  Autoradiographic analysis of altered glycosaminoglycan synthesis in the epiphyseal cartilage of neonatal brachymorphic mice.

Authors:  R M Greene; K S Brown; R M Pratt
Journal:  Anat Rec       Date:  1978-05
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  1 in total

1.  The queen conch mitogenome: intra- and interspecific mitogenomic variability in Strombidae and phylogenetic considerations within the Hypsogastropoda.

Authors:  Salima Machkour-M'Rabet; Margaret M Hanes; Josué Jacob Martínez-Noguez; Jorge Cruz-Medina; Francisco J García-De León
Journal:  Sci Rep       Date:  2021-06-07       Impact factor: 4.379
  1 in total

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