Literature DB >> 6274250

Biochemical characterization of the genetic variants of human phosphoglycolate phosphatase (PGP).

V S Turner, D A Hopkinson.   

Abstract

Phosphoglycolate phosphatase (PGP) exhibits a wide range of activities in normal human red cells. Analysis of blood from 57 individuals of known PGP phenotype revealed no correlation between enzyme activity, electrophoretic phenotype or 2,3-DPG concentration. Neither was there evidence of variation in Km, heat stability, pH optimum or molecular size among the various electrophoretic phenotypes. However, human red cell PGP exhibits high (0.24 mM) and low (0.05 mM) Km values for phosphoglycolate irrespective of phenotype and this requires further analysis.

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Year:  1981        PMID: 6274250     DOI: 10.1111/j.1469-1809.1981.tb00313.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN: 0003-4800            Impact factor:   1.670


  4 in total

1.  Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.

Authors:  Annegrit Seifried; Gunnar Knobloch; Prashant S Duraphe; Gabriela Segerer; Julia Manhard; Hermann Schindelin; Jörg Schultz; Antje Gohla
Journal:  J Biol Chem       Date:  2013-12-13       Impact factor: 5.157

2.  [The use of and value as evidence of polymorphism of phosphoglycolate phosphatase (E.C. 3.1.3.18) in forensic medicine].

Authors:  H J Christoph; B Brinkmann
Journal:  Z Rechtsmed       Date:  1984

3.  Human placental alkaline phosphatase electrophoretic alleles: quantitative studies.

Authors:  P Lucarelli; R Scacchi; R M Corbo; A Benincasa; R Palmarino
Journal:  Am J Hum Genet       Date:  1982-03       Impact factor: 11.025

4.  Population, formal genetics, and linkage relations of the phosphoglycolate phosphatase (PGP)--E.C.3.1.3.18.

Authors:  W Brink; M P Baur; C Rittner
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

  4 in total

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