Literature DB >> 6273400

cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils.

J A Badwey, J T Curnutte, M L Karnovsky.   

Abstract

Arachidonate stimulates the production of large quantities of superoxide by human neutrophils: 93.8 +/- 12.5 S.D. nmol of O2(-)/min/10(7) cells. This rate is comparable to that observed with the most effective neutrophil-stimulating agents previously reported. Other cis-unsaturated fatty acids are also capable of eliciting this response, the order of effectiveness being: arachidonate greater than gamma-linolenate greater than linoleate greater than oleate. Linolelaidate, myristate, and palmitate are ineffective. These data are discussed in relation to recent reports concerning the oxidation of arachidonic acid by human neutrophils and by a cell-free system that generates superoxide and hydrogen peroxide.

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Year:  1981        PMID： 6273400

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  42 in total

1.  Playing "telephone": bioactive lipids as mediators of intercompartmental communication in the alveolus.

Authors:  M Peters-Golden
Journal:  J Clin Invest       Date:  2000-04       Impact factor: 14.808

Review 2.  Arachidonic acid as a bioactive molecule.

Authors:  A R Brash
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

3.  Effect of 22-32 carbon n-3 polyunsaturated fatty acids on superoxide production in human neutrophils: synergism of docosahexaenoic acid with f-met-leu-phe and phorbol ester.

Authors:  A Poulos; B S Robinson; A Ferrante; D P Harvey; S J Hardy; A W Murray
Journal:  Immunology       Date:  1991-05       Impact factor: 7.397

4.  Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

Authors:  C F Nathan
Journal:  J Clin Invest       Date:  1987-12       Impact factor: 14.808

5.  Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

Authors:  M E Brezinski; C N Serhan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

6.  Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid.

Authors:  V V Cherny; L M Henderson; W Xu; L L Thomas; T E DeCoursey
Journal:  J Physiol       Date:  2001-09-15       Impact factor: 5.182

7.  Inhibition of neutrophil response by curcumin.

Authors:  R Srivastava
Journal:  Agents Actions       Date:  1989-11

8.  Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase.

Authors:  L M Henderson; J B Chappell; O T Jones
Journal:  Biochem J       Date:  1989-11-15       Impact factor: 3.857

9.  Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation.

Authors:  R M Clancy; C A Dahinden; T E Hugli
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

10.  Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis.

Authors:  M Peters-Golden; K Song; T Marshall; T Brock
Journal:  Biochem J       Date:  1996-09-15       Impact factor: 3.857
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