Literature DB >> 6273187

On the opioid nature of phencyclidine and its 3-hydroxy derivative.

Y Itzhak, A Kalir, Y Sarne.   

Abstract

Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of alpha- and mu-receptors in the opioid effects of these drugs is discussed.

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Year:  1981        PMID： 6273187     DOI： 10.1016/0014-2999(81)90097-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Solubilization and characterization of mu, delta, and kappa opioid binding sites from guinea pig brain: physical separation of kappa receptors.

Authors:  Y Itzhak; J M Hiller; E J Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

2.  Effects of phencyclidine, haloperidol, and naloxone on fixed-interval performance in rats.

Authors:  G C Wagner; D B Masters; A Tomie
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

3.  Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat.

Authors:  S Castellani; A J Giannini; P M Adams
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

4.  Circling behavior induced by phencyclidine in mice and its inhibition by naloxone.

Authors:  Y Eshel; A M Korczyn
Journal:  Experientia       Date:  1985-01-15
  4 in total

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