Literature DB >> 6273006

A phase II clinical study of mAMSA in small cell carcinoma of the lung.

P J Dady, A P Sappino, A Rudd, I E Smith.   

Abstract

Thirteen patients with small cell carcinoma of the bronchus that had become resistant to conventional chemotherapy were given 4'-(9-acridinylamino)methanesulphon-m-anisidide (mAMSA) at a dose of 90 or 120 mg/m2 at 3-week intervals. Twenty percent of the courses at 90 mg/m2 produced marked myelosuppression. No responses were observed. Median survival from the start of treatment with mAMSA was 5 weeks.

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Year:  1981        PMID: 6273006     DOI: 10.1007/bf00262342

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN: 0344-5704            Impact factor:   3.333


  7 in total

1.  The pharmacologic disposition of 4'-(9-acridinylamino)methanesulfon-m-anisidide in mice and rats.

Authors:  R L Cysyk; D Shoemaker; R H Adamson
Journal:  Drug Metab Dispos       Date:  1977 Nov-Dec       Impact factor: 3.922

2.  The experimental antitumour properties of three congeners of the acridylmethanesulphonanilide (AMSA) series.

Authors:  B F Cain; G J Atwell
Journal:  Eur J Cancer       Date:  1974-08       Impact factor: 9.162

3.  Phase I study of methanesulfonamide, N-[4-(9-acridinylamino)-3-methoxyphenyl]-(m-AMSA) using a single-dose schedule.

Authors:  D D Von Hoff; K Howser; P Gormley; R A Bender; D Glaubiger; A S Levine; R C Young
Journal:  Cancer Treat Rep       Date:  1978-10

4.  Neurologic and cardiac rhythm abnormalities associated with 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) therapy.

Authors:  S S Legha; J Latreille; K B McCredie; G P Bodey
Journal:  Cancer Treat Rep       Date:  1979 Nov-Dec

5.  Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in metastatic breast cancer.

Authors:  S S Legha; G R Blumenschein; A U Buzdar; G N Hortobagyi; G P Bodey
Journal:  Cancer Treat Rep       Date:  1979 Nov-Dec

6.  Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia.

Authors:  Z A Arlin; R B Sklaroff; T S Gee; S J Kempin; J Howard; B D Clarkson; C W Young
Journal:  Cancer Res       Date:  1980-09       Impact factor: 12.701

7.  Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.

Authors:  R J Schneider; T M Woodcock; A Yagoda
Journal:  Cancer Treat Rep       Date:  1980-01
  7 in total

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