| Literature DB >> 6272937 |
A S Levine, J E Morley, J Kneip, M Grace, S E Silvis.
Abstract
Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occurred in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of D-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric acid secretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.Entities:
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Year: 1981 PMID： 6272937 DOI： 10.1016/0006-8993(81)90770-8
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252