Literature DB >> 6272752

Effect of prevention of procollagen triple-helix formation on proline 3-hydroxylation in freshly isolated chick-embryo tendon cells.

K Majamaa.   

Abstract

Inhibition of procollagen triple-helix formation by the addition of cis-hydroxyproline or azetidine-2-carboxylic acid increased the synthesis of 3-hydroxy[14C]proline 1.7-1.8-fold in pulse-chase experiments with freshly isolated chick-embryo tendon cells. The amount of 3-hydroxy[14C]proline, expressed as a percentage of the total 14C radioactivity in hydroxyproline, reached 8.4%. Control experiments indicated that the two analogues had no effect on the prolyl 3-hydroxylase activity of these cells. The data suggest that the time available before triple-helix formation in part regulates the extent of the 3-hydroxylation of proline in the biosynthesis of collagen in intact cells.

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Year:  1981        PMID： 6272752      PMCID： PMC1162983          DOI： 10.1042/bj1960203

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  28 in total

1.  Incorporation of cis-hydroxyproline into collagen by tendon cells. Failure of the intracellular collagen to assume a triple-helical conformation.

Authors:  J Uitto; P Dehm; D J Prockop
Journal:  Biochim Biophys Acta       Date:  1972-10-31

2.  The biosynthesis of basement membrane collagen in embryonic chick lens. 3. Intracellular formation of the triple helix and the formation of aggregates through disulfide bonds.

Authors:  M E Grant; J D Schofield; N A Kefalides; D J Prockop
Journal:  J Biol Chem       Date:  1973-11-10       Impact factor: 5.157

3.  Rate of helix formation by intracellular procollagen and protocollagen. Evidence for a role for disulfide bonds.

Authors:  J Uitto; D J Prockop
Journal:  Biochem Biophys Res Commun       Date:  1973-12-10       Impact factor: 3.575

4.  Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells.

Authors:  J D Schofield; J Uitto; D J Prockop
Journal:  Biochemistry       Date:  1974-04-23       Impact factor: 3.162

5.  Biosynthesis of cartilage procollagen.

Authors:  P Dehm; D J Prockop
Journal:  Eur J Biochem       Date:  1973-05

6.  Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine.

Authors:  P Dehm; D J Prockop
Journal:  Biochim Biophys Acta       Date:  1972-04-21

7.  The biosynthesis of basement membrane collagen in embryonic chick lens. I. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells.

Authors:  M E Grant; N A Kefalides; D J Prockop
Journal:  J Biol Chem       Date:  1972-06-10       Impact factor: 5.157

Review 8.  Prolyl hydroxylase.

Authors:  G J Cardinale; S Udenfriend
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1974

9.  Biosynthesis of abnormal collagens with amino acid analogues. I. Incorporation of L-azetidine-2-carboxylic acid and cis-4-fluoro-L-proline into protocollagen and collagen.

Authors:  T Takeuchi; D J Prockop
Journal:  Biochim Biophys Acta       Date:  1969-02-04

10.  Partial purification and characterization of chick-embryo prolyl 3-hydroxylase.

Authors:  K Tryggvason; K Majamaa; J Risteli; K I Kivirikko
Journal:  Biochem J       Date:  1979-11-01       Impact factor: 3.857
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