Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inhibition of bone resorption in culture by inhibitors of thiol proteinases.

Literature DB >> 6272702

Inhibition of bone resorption in culture by inhibitors of thiol proteinases.

Abstract

Leupeptin, antipain, tosyl-lysylchloromethane (Tos-Lys-CH2Cl) and benzyloxy-carbonylphenylalanylalanyldiazomethane (Z-Phe-Ala-CHN2) inhibit reversibly the resorption induced by parathyroid hormone or heparin in cultured mouse bones. Leupeptin and antipain do not affect collagenase production and activity or the enhanced secretion of beta-glucuronidase induced by the bone-resorbing agents. They might thus act by a direct (extracellular?) inhibition of lysosomal thiol proteinases.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1980 PMID： 6272702 PMCID： PMC1162343 DOI： 10.1042/bj1920365

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

9 in total

1. Proteolytic enzymes, cell surface changes, and viral transformation.

Authors: R Robin; I N Chou; P H Black
Journal: Adv Cancer Res Date: 1975 Impact factor: 6.242

2. The release of collagenase as an inactive proenzyme by bone explants in culture.

Authors: G Vaes
Journal: Biochem J Date: 1972-01 Impact factor: 3.857

3. Excretion of acid and of lysosomal hydrolytic enzymes during bone resorption induced in tissue culture by parathyroid extract.

Authors: G Vaes
Journal: Exp Cell Res Date: 1965-09 Impact factor: 3.905

4. Glycosidases in the nervous system. I. Assay, some properties, and distribution of beta-galactosidase, beta-glucoronidase, and beta-glucosidase.

Authors: E Robins; H E Hirsch; S S Emmons
Journal: J Biol Chem Date: 1968-08-25 Impact factor: 5.157

5. Purification of bovine spleen collagenolytic cathepsin, (cathepsin N).

Authors: A Ducastaing; D J Etherington
Journal: Biochem Soc Trans Date: 1978 Impact factor: 5.407

6. Collagenase, procollagenase and bone resorption. Effects of heparin, parathyroid hormone and calcitonin.

Authors: G Lenaers-Claeys; G Vaes
Journal: Biochim Biophys Acta Date: 1979-05-16

7. The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases.

Authors: E Shaw; R T Dean
Journal: Biochem J Date: 1980-02-15 Impact factor: 3.857

8. Cathepsin B1. A lysosomal enzyme that degrades native collagen.

Authors: M C Burleigh; A J Barrett; G S Lazarus
Journal: Biochem J Date: 1974-02 Impact factor: 3.857

9. On the mechanisms of bone resorption. The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by bone cells.

Authors: G Vaes
Journal: J Cell Biol Date: 1968-12 Impact factor: 10.539

9 in total

14 in total

1. Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors.

Authors: J Anagli; J Hagmann; E Shaw
Journal: Biochem J Date: 1991-03-01 Impact factor: 3.857

2. Electron microscopy of developing calvaria reveals images that suggest that osteoclasts engulf and destroy osteocytes during bone resorption.

Authors: A S Elmardi; M V Katchburian; E Katchburian
Journal: Calcif Tissue Int Date: 1990-04 Impact factor: 4.333

3. Metabolic studies on connective tissue collagens in bone and tendon of adjuvant arthritic rat.

Authors: G K Reddy; S C Dhar
Journal: Calcif Tissue Int Date: 1992-04 Impact factor: 4.333

Review 4. Control mechanisms in bone resorption: 240 years after John Hunter.

Authors: M C Meikle
Journal: Ann R Coll Surg Engl Date: 1997-01 Impact factor: 1.891

5. Evidence for two pathways for stimulation of collagenolysis in bone.

Authors: R L Jilka; J W Hamilton
Journal: Calcif Tissue Int Date: 1985-05 Impact factor: 4.333

6. Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption.

Authors: V Everts; W Beertsen; R Schröder
Journal: Calcif Tissue Int Date: 1988-09 Impact factor: 4.333

7. Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase.

Authors: J M Delaissé; P Ledent; G Vaes
Journal: Biochem J Date: 1991-10-01 Impact factor: 3.857