Literature DB >> 6271688

Evidence that the spontaneous blastogenesis of lymphocytes from bovine leukemia virus-infected cattle is viral antigen specific.

R M Thorn, P Gupta, S J Kenyon, J F Ferrer.   

Abstract

Cattle lymphocytes cultured for 3 days were found to spontaneously incorporate thymidine (3STI). Under optimal conditions of culture, the median magnitude of 3STI activity in lymphocytes from bovine leukemia virus (BLV)-infected cattle was higher than that of BLV-free cattle, but the ranges of the values overlapped. However, the 3STI activity of most BLV-infected cattle was specifically inhibited by serum containing BLV antibodies, whereas the 3STI activity of BLV-free cattle was not. The 3STI inhibitor copurified with immunoglobulin, and its activity could be absorbed with BLV. Rabbit anti-BLV serum inhibited 3STI, but rabbit anti-BLV p25 did not. These results indicate that BLV infection induces or expands a BLV-specific lymphocyte population. Spontaneous blastogenesis may be indicative of an immune response which controls virus spread.

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Year:  1981        PMID： 6271688      PMCID： PMC350824          DOI： 10.1128/iai.34.1.84-89.1981

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

1.  OCCURRENCE OF LYMPHOCYTOSIS IN DAIRY CATTLE HERDS WITH HIGH INCIDENCE OF LYMPHOSARCOMA.

Authors:  R R MARSHAK; W C HARE; D A ABT; J E CROSHAW; J W SWITZER; I IPSEN; R M DUTCHER; J E MARTIN
Journal:  Ann N Y Acad Sci       Date:  1963-11-04       Impact factor: 5.691

2.  A simplified 51Cr-release assay for killer cells.

Authors:  R M Thorn; J C Palmer; L A Manson
Journal:  J Immunol Methods       Date:  1974-03       Impact factor: 2.303

3.  Characteristics of lymphocyte responses to phytomitogens: comparison of responses of lymphocytes from normal and lymphocytotic cows.

Authors:  C C Muscoplat; I Alhaji; D W Johnson; K A Pomeroy; J M Olson; V L Larson; J B Stevens; D K Sorensen
Journal:  Am J Vet Res       Date:  1974-08       Impact factor: 1.156

4.  Abnormalities in lymphocyte proliferation in classical and atypical measles infection.

Authors:  A Finkel; P B Dent
Journal:  Cell Immunol       Date:  1973-01       Impact factor: 4.868

5.  Two categories of lymphocyte unresponsiveness to phytohemagglutinin.

Authors:  C E Buckley; M J Zitt; T R Cate
Journal:  Cell Immunol       Date:  1973-01       Impact factor: 4.868

6.  DNA and RNA synthesis in cultures of peripheral blood mononuclear leucocytes from normal and lymphosarcomatous cows.

Authors:  T J Yang; W C Hare; D A Abt
Journal:  Br J Haematol       Date:  1967-11       Impact factor: 6.998

7.  Bovine leukemia virus: an exogenous RNA oncogenic virus.

Authors:  R Kettmann; D Portetelle; M Mammerickx; Y Cleuter; D Dekegel; M Galoux; J Ghysdael; A Burny; H Chantrenne
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

8.  Reaction of human lymphocytes in culture to components of the medium.

Authors:  G J Johnson; P S Russell
Journal:  Nature       Date:  1965-10-23       Impact factor: 49.962

9.  Cytogenetic, cytological, and virological characteristics of a bovine fibrosarcoma.

Authors:  C A Diglio; W C Hare; D C Dodd; R R Marshak; J F Ferrer
Journal:  Cancer Res       Date:  1975-12       Impact factor: 12.701

10.  Studies on the relationship between infection with bovine C-type virus, leukemia, and persistent lymphocytosis in cattle.

Authors:  J F Ferrer; D A Abt; D M Bhatt; R R Marshak
Journal:  Cancer Res       Date:  1974-04       Impact factor: 12.701
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  6 in total

1.  Intestinal Shiga toxin-producing Escherichia coli bacteria mitigate bovine leukemia virus infection in experimentally infected sheep.

Authors:  Witold A Ferens; Rowland Cobbold; Carolyn J Hovde
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

2.  Phytohemagglutinin activation of the transcription of the bovine leukemia virus genome requires de novo protein synthesis.

Authors:  R Chatterjee; P Gupta; S V Kashmiri; J F Ferrer
Journal:  J Virol       Date:  1985-06       Impact factor: 5.103

3.  Antiviral activity of shiga toxin 1: suppression of bovine leukemia virus-related spontaneous lymphocyte proliferation.

Authors:  W A Ferens; C J Hovde
Journal:  Infect Immun       Date:  2000-08       Impact factor: 3.441

4.  B-lymphocyte proliferation during bovine leukemia virus-induced persistent lymphocytosis is enhanced by T-lymphocyte-derived interleukin-2.

Authors:  E S Trueblood; W C Brown; G H Palmer; W C Davis; D M Stone; T F McElwain
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

5.  Antiviral activity of shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells.

Authors:  Indira Basu; Witold A Ferens; Diana M Stone; Carolyn J Hovde
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

6.  Inhibition of protein kinase C results in decreased expression of bovine leukemia virus.

Authors:  W A Jensen; B J Wicks-Beard; G L Cockerell
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103
  6 in total

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