Literature DB >> 6271336

Baclofen selectively inhibits excitatory synaptic transmission in the hippocampus.

T H Lanthorn, C W Cotman.   

Abstract

The effect of baclofen was investigated on mossy fiber, Schaffer collateral and perforant path synaptic transmission in hippocampal slices. Baclofen completely inhibits mossy fiber and Schaffer collateral synaptic transmission with an IC50 of 3.8 microM. The lateral perforant path is insensitive to baclofen, while the response in the medial zone was partially blocked. Baclofen does not appear to act in a GABA-like manner.

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Year:  1981        PMID： 6271336     DOI： 10.1016/0006-8993(81)90326-7

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  44 in total

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Authors:  I V Batueva; J T Buchanan; E A Tsvetkov; A K Sagatelyan; N P Veselkin
Journal:  Neurosci Behav Physiol       Date:  1999 Jan-Feb

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Authors:  Chinfei Chen; Wade G Regehr
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3.  Chronic lesion of corticostriatal fibers reduces GABAB but not GABAA binding in rat caudate putamen: an autoradiographic study.

Authors:  R Moratalla; N G Bowery
Journal:  Neurochem Res       Date:  1991-03       Impact factor: 3.996

Review 4.  Viagra for your synapses: Enhancement of hippocampal long-term potentiation by activation of beta-adrenergic receptors.

Authors:  Thomas J O'Dell; Steven A Connor; Jennifer N Gelinas; Peter V Nguyen
Journal:  Cell Signal       Date:  2009-12-31       Impact factor: 4.315

5.  Presynaptic inhibition preferentially reduces in NMDA receptor-mediated component of transmission in rat midbrain dopamine neurons.

Authors:  Y N Wu; K Z Shen; S W Johnson
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

6.  The effects of baclofen and two GABAB-receptor antagonists on long-term potentiation.

Authors:  H R Olpe; G Karlsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-08       Impact factor: 3.000

7.  GIRK1 immunoreactivity is present predominantly in dendrites, dendritic spines, and somata in the CA1 region of the hippocampus.

Authors:  C T Drake; S B Bausch; T A Milner; C Chavkin
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-04       Impact factor: 11.205

8.  Cholinergic phosphatidylinositol modulation of inhibitory, G protein-linked neurotransmitter actions: electrophysiological studies in rat hippocampus.

Authors:  P F Worley; J M Baraban; M McCarren; S H Snyder; B E Alger
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

9.  GABAB receptor-mediated inhibition of Ca2+ currents and synaptic transmission in cultured rat hippocampal neurones.

Authors:  K P Scholz; R J Miller
Journal:  J Physiol       Date:  1991-12       Impact factor: 5.182

10.  Anticonvulsant-like actions of baclofen in the rat hippocampal slice.

Authors:  B Ault; J V Nadler
Journal:  Br J Pharmacol       Date:  1983-04       Impact factor: 8.739
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