Literature DB >> 627058

Automated assay of gamma-aminobutyric acid in human cerebrospinal fluid.

P Böhlen, P J Schechter, W van Damme, G Coquillat, J C Dosch, J Koch-Weser.   

Abstract

We describe an automated amino acid analyzer with fluorescence detection (o-phthalaldehyde) which permits sensitive and rapid determinations of gamma aminobutyric acid in human cerebrospinal fluid. Concentrations as low as 50 nmol/liter can be accurately determined in 100 mul samples at the rate of one sample per hour. Concentrations in untreated cerebrospinal fluid increase rapidly after sampling by lumbar puncture. The concentration in immediately deproteinized samples from 38 patients with intervertebral disc disorders was 220 +/- 81 nmol/liter (mean +/- SD).

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Year:  1978        PMID： 627058

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  6 in total

Review 1.  Clinical relevance of measuring GABA concentrations in cerebrospinal fluid.

Authors:  P J Schechter; A Sjoerdsma
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

Review 2.  Review: Normal and abnormal central nervous system GABA metabolism in childhood.

Authors:  J Jaeken; P Casaer; K D Haegele; P J Schechter
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

3.  Free-GABA levels in the cerebrospinal fluid of patients suffering from several neurological diseases Its potential use for the diagnosis of diseases which course with inflammation and tissular necrosis.

Authors:  A T Zepeda; F J Ortiz Nesme; J Méndez-Franco; E Otero-Siliceo; M Pérez de la Mora
Journal:  Amino Acids       Date:  1995-09       Impact factor: 3.520

Review 4.  Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid.

Authors:  T A Hare
Journal:  Mol Cell Biochem       Date:  1981-09-25       Impact factor: 3.396

5.  Measurement of release of endogenous GABA and catabolites of [3H]GABA from synaptosomal preparations using ion-exchange chromatography.

Authors:  J Grove; C R Gardner; M H Richards
Journal:  Neurochem Res       Date:  1982-05       Impact factor: 3.996

6.  Meige syndrome: double-blind crossover study of sodium valproate.

Authors:  J W Snoek; T W van Weerden; A W Teelken; W van den Burg; J P Lakke
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-11       Impact factor: 10.154
  6 in total

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